Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 11/20 | 0.37 |
| ▸ | CDK2 | P24941 | 11/20 | 0.37 |
| ▸ | CCNO | P22674 | 2/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.32 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771166 | 0.86 | OPRM1 (0.32) | MEN1LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6770739 | 0.85 | CCNA2 (0.45) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6776854 | 0.85 | PTGS1 (0.42) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6772430 | 0.84 | CCNA2 (0.44) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6775773 | 0.82 | CCNA2 (0.39) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6772549 | 0.81 | CCNA2 (0.35) | CCNA2CDK2MEN1LMNACYP1A2 | |
| SCHEMBL6771336 | 0.80 | CCNA2 (0.37) | CCNA2CDK2MEN1LMNACYP1A2 | |
| SCHEMBL6772794 | 0.78 | CCNA2 (0.40) | CCNA2CDK2MEN1HTTKMT2A | |
| SCHEMBL6772109 | 0.78 | CCNA2 (0.37) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6163663 | 0.76 | ALDH1A1 (0.35) | CCNA2CDK2CCNOCCNE1CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |