Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.58 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.50 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8746152 | 0.86 | LTA4H (0.55) | LTA4HAPPHDAC1CHRNB4CHRNA3 | |
| SCHEMBL2489895 | 0.85 | LTA4H (0.51) | LTA4HAPPHDAC1CHRNB4CHRNA3 | |
| SCHEMBL1196073 | 0.83 | LTA4H (0.58) | LTA4HAPPHDAC1CHRNB4CHRNA3 | |
| SCHEMBL8746105 | 0.83 | HDAC1 (0.54) | LTA4HHDAC1NPC1DRD2DRD3 | |
| SCHEMBL8746082 | 0.82 | HDAC1 (0.56) | LTA4HHDAC1NPC1DRD2DRD3 | |
| SCHEMBL8746072 | 0.82 | HDAC1 (0.56) | LTA4HHDAC1NPC1DRD2DRD3 | |
| SCHEMBL329575 | 0.82 | ALOX5 (0.62) | LTA4HNPC1KDM4EPLA2G2AMAOA | |
| SCHEMBL3794813 | 0.81 | LTA4H (0.60) | LTA4HAPPHDAC1CHRNB4CHRNA3 | |
| SCHEMBL14481578 | 0.81 | LTA4H (0.60) | LTA4HAPPHDAC1CHRNB4CHRNA3 | |
| SCHEMBL3793622 | 0.81 | LTA4H (0.60) | LTA4HAPPHDAC1CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6750242-B1 | Positive modulators of nicotinic receptor agonists | ASTRAZENECA AB (SE) | 2004-06-15 | — | — | US | claimed |
| EP-1230216-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | AstraZeneca AB (SE) | 2002-08-14 | — | — | EP | claimed |
| WO-2001032619-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2001-05-10 | — | — | WO | claimed |
| US-6750242-B1 | Positive modulators of nicotinic receptor agonists | ASTRAZENECA AB (SE) | 2004-06-15 | — | — | US | disclosed |
| EP-1230216-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | AstraZeneca AB (SE) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001032619-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2001-05-10 | — | — | WO | disclosed |