Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6769928 | 0.93 | RPS6KB1 (0.52) | SYKALDH1A1LMNAMAPTRPS6KB1 | |
| SCHEMBL6608523 | 0.91 | SYK (0.48) | SYKLMNAMAPTRPS6KB1PDGFRB | |
| SCHEMBL6777397 | 0.88 | SYK (0.46) | SYKLMNAMAPTRPS6KB1PDGFRB | |
| SCHEMBL6769860 | 0.85 | SYK (0.52) | SYKLMNAMAPTRPS6KB1PDGFRB | |
| SCHEMBL20354302 | 0.85 | SYK (0.52) | SYKALDH1A1LMNAMAPTRPS6KB1 | |
| SCHEMBL6766170 | 0.84 | KDR (0.46) | SYKALDH1A1RPS6KB1PDGFRBPDGFRA | |
| SCHEMBL761284 | 0.83 | SYK (0.54) | SYKRPS6KB1PDGFRBPDGFRAMAPK1 | |
| SCHEMBL6610211 | 0.83 | SYK (0.55) | SYKALDH1A1MAPTRPS6KB1PDGFRB | |
| SCHEMBL6770452 | 0.83 | RPS6KB1 (0.51) | SYKLMNAMAPTRPS6KB1MAPK1 | |
| SCHEMBL6769391 | 0.83 | PDGFRB (0.66) | SYKPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6762189-B1 | HEPATITIS B VIRUS AND HUMAN IMMUNODEFICIENCY VIRUS ANTIPROLIFERATION AGENTS; REDUCED CHANCE OF TOXICITY, SIDE EFFECTS, AND DEVELOPMENT OF RESISTANT VIRAL STRAINS | DONG WHA PHARM. IND. CO., LTD. (KR) | 2004-07-13 | — | — | US | disclosed |