Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.40 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6767259 | 0.87 | SRC (0.40) | SRCLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL6164455 | 0.87 | ABCG2 (0.47) | CSNK2A2CSNK2BCSNK2A1ABCG2CSNK2A3 | |
| SCHEMBL6775862 | 0.86 | ABCG2 (0.39) | SRCCSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL6777711 | 0.84 | OPRM1 (0.45) | SRCLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL6769517 | 0.83 | SRC (0.39) | SRCCSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL6769518 | 0.83 | L3MBTL1 (0.49) | CSNK2A2CSNK2BCSNK2A1ABCG2CSNK2A3 | |
| SCHEMBL6771222 | 0.82 | OPRM1 (0.47) | SRCCSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL6770768 | 0.81 | SRC (0.41) | SRCCSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL6769466 | 0.81 | SRC (0.53) | SRCLMNAKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6770603 | 0.80 | CSNK2A2 (0.40) | CSNK2A2CSNK2BCSNK2A1ABCG2CSNK2A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |