Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.36 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168193 | 0.86 | ABCG2 (0.42) | OPRM1CSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL6772323 | 0.86 | GPBAR1 (0.41) | OPRM1SRCKMT2AALDH1A1MEN1 | |
| SCHEMBL6777711 | 0.85 | OPRM1 (0.45) | OPRM1SRCDRD2DRD3KCNH2 | |
| SCHEMBL6770751 | 0.85 | OPRM1 (0.45) | OPRM1SRCKMT2AALDH1A1MEN1 | |
| SCHEMBL6770768 | 0.82 | SRC (0.41) | OPRM1SRCDRD2DRD3KCNH2 | |
| SCHEMBL6770441 | 0.82 | SRC (0.41) | SRCDRD2DRD3KCNH2GRM5 | |
| SCHEMBL6771814 | 0.81 | SRC (0.60) | OPRM1SRCKMT2AALDH1A1MAPK1 | |
| SCHEMBL6771042 | 0.81 | ALDH1A1 (0.44) | SRCDRD2DRD3KCNH2CSNK2A2 | |
| SCHEMBL6767529 | 0.80 | OPRM1 (0.72) | OPRM1SRCKMT2AALDH1A1MEN1 | |
| SCHEMBL6769517 | 0.80 | SRC (0.39) | SRCDRD2DRD3KCNH2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |