Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 3/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6770073 | 0.87 | MAPT (0.34) | MAPTMEN1KMT2ADHODHPDE4A | |
| SCHEMBL6770582 | 0.82 | PDE4A (0.34) | CACNA2D1MAPTMEN1KMT2ADHODH | |
| SCHEMBL6771854 | 0.80 | MAPT (0.33) | MAPTDHODHPDE4APDE4BPDE4C | |
| SCHEMBL6771220 | 0.79 | MAPT (0.33) | MAPTDHODHPDE4APDE4BPDE4C | |
| SCHEMBL6776532 | 0.69 | SRC (0.36) | MAPTMEN1KMT2ADHODHPDE4A | |
| SCHEMBL6769771 | 0.66 | MAPT (0.37) | MAPTDHODHPDE4APDE4BPDE4C | |
| SCHEMBL7533976 | 0.63 | PARP1 (0.33) | MAPTMEN1KMT2ADHODH | |
| SCHEMBL6771777 | 0.63 | OPRM1 (0.46) | — | |
| SCHEMBL6766716 | 0.62 | HTT (0.37) | CACNA2D1MAPT | |
| SCHEMBL6164280 | 0.62 | OPRM1 (0.45) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |