Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.30 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.30 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6163485 | 0.89 | ALDH1A1 (0.38) | HTTLMNATSHROPRM1ALDH1A1 | |
| SCHEMBL6767118 | 0.87 | HTT (0.40) | HTTLMNATSHROPRM1ALDH1A1 | |
| SCHEMBL6771777 | 0.83 | OPRM1 (0.46) | LMNAOPRM1ALDH1A1 | |
| SCHEMBL6772625 | 0.83 | CSNK2A2 (0.34) | CACNA2D1CSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL6776683 | 0.82 | LMNA (0.46) | HTTLMNATSHROPRM1ALDH1A1 | |
| SCHEMBL6771327 | 0.82 | DHODH (0.32) | — | |
| SCHEMBL6778055 | 0.81 | SRC (0.43) | HTTLMNATSHROPRM1ALDH1A1 | |
| SCHEMBL6164396 | 0.79 | ALDH1A1 (0.41) | HTTLMNATSHRALDH1A1MAPT | |
| SCHEMBL6776541 | 0.78 | ALDH1A1 (0.47) | HTTLMNATSHROPRM1ALDH1A1 | |
| SCHEMBL6163994 | 0.78 | HTT (0.39) | HTTLMNATSHROPRM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |