Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2447211 | 0.78 | KDM4E (0.44) | KMT2AMEN1L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL2187375 | 0.76 | KMT2A (0.42) | KMT2AMEN1L3MBTL1MAPK1TDP1 | |
| SCHEMBL4722008 | 0.74 | ALDH1A1 (0.39) | KMT2AMEN1L3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL13836388 | 0.73 | KMT2A (0.48) | KMT2AMEN1L3MBTL1MAPK1TDP1 | |
| SCHEMBL3140391 | 0.72 | KMT2A (0.44) | KMT2AMEN1L3MBTL1MAPK1TDP1 | |
| SCHEMBL11904484 | 0.70 | CYP2A6 (0.39) | KMT2AMEN1MAPK1TDP1ALDH1A1 | |
| SCHEMBL577790 | 0.70 | ALDH1A1 (0.51) | KMT2AMEN1MAPK1TDP1ALDH1A1 | |
| SCHEMBL4724198 | 0.70 | TLR8 (0.49) | KMT2AMEN1ALDH1A1MAPTGAA | |
| SCHEMBL17197377 | 0.69 | ALDH1A1 (0.47) | KMT2AMEN1L3MBTL1MAPK1TDP1 | |
| SCHEMBL628270 | 0.69 | ALDH1A1 (0.43) | KMT2AMEN1L3MBTL1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806274-B1 | IMMUNOREGULATION OR IMMUNOSUPPRESSIVE AGENTS; TYROSINE KINASE INHIBITORS; PREVENTING ORGAN TRANSPLANT REJECTION; AUTOIMMUNE CONDITIONS; REDUCED SIDE EFFECTS | ASTRAZENECA UK LIMITED (GB) | 2004-10-19 | — | — | US | disclosed |