Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CCR1 | P32246 | 2/20 | 0.44 |
| ▸ | CCR5 | P51681 | 2/20 | 0.44 |
| ▸ | CCR8 | P51685 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6770764 | 0.78 | KMT2A (0.37) | KDM4ELMNATSHRSMN1; SMN2TDP1 | |
| SCHEMBL2187375 | 0.78 | KMT2A (0.42) | KDM4ELMNATSHRSMN1; SMN2TDP1 | |
| SCHEMBL1385432 | 0.77 | ALDH1A1 (0.42) | KDM4ETSHRSMN1; SMN2TDP1TP53 | |
| SCHEMBL4722008 | 0.75 | ALDH1A1 (0.39) | KDM4ELMNATSHRSMN1; SMN2TP53 | |
| SCHEMBL2320187 | 0.74 | KDM4E (0.47) | KDM4ELMNATSHRCCR1CCR5 | |
| SCHEMBL9032374 | 0.74 | CYP1A2 (0.49) | KDM4ESMN1; SMN2TP53CYP3A4MAPT | |
| SCHEMBL938744 | 0.73 | ALDH1A1 (0.40) | KDM4ECCR1CCR8TDP1MAPT | |
| SCHEMBL15229223 | 0.73 | ALDH1A1 (0.43) | KDM4ETSHRSMN1; SMN2TP53HSP90AA1 | |
| SCHEMBL12853981 | 0.72 | LMNA (0.68) | KDM4ELMNAMMP2TSHRCCR1 | |
| SCHEMBL29377530 | 0.72 | CYP2A6 (0.55) | KDM4ELMNAMMP2TSHRCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009003952-A2 | COLUMN AND METHOD FOR PREPARING A BIOLOGICAL SAMPLE FOR PROTEIN PROFILING | PRONOTA N.V. (BE) | 2009-01-08 | — | — | WO | claimed |
| EP-3180003-B1 | PKC-EPSILON INHIBITORS | UNIV CALIFORNIA (US) | 2022-01-12 | — | — | EP | disclosed |
| US-20210145838-A1 | SELECTIVE PDE4D INHIBITORS AGAINST DEMYELINATING DISEASES | UNIVERSITEIT MAASTRICHT (BE) | 2021-05-20 | — | — | US | disclosed |
| EP-3773562-A1 | SELECTIVE PDE4D INHIBITORS AGAINST DEMYELINATING DISEASES | Universiteit Hasselt (BE) | 2021-02-17 | — | — | EP | disclosed |
| US-10738002-B2 | Halogenated benzotropolones as ATG4B inhibitors | UNIVERSITAIR ZIEKENHUIS ANTWERPEN (BE) | 2020-08-11 | — | — | US | disclosed |
| WO-2019193091-A1 | SELECTIVE PDE4D INHIBITORS AGAINST DEMYELINATING DISEASES | UNIVERSITEIT HASSELT (BE) | 2019-10-10 | — | — | WO | disclosed |
| EP-3544952-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | Universiteit Antwerpen (BE) | 2019-10-02 | — | — | EP | disclosed |
| US-20190284130-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | UNIVERSITEIT ANTWERPEN (BE) | 2019-09-19 | — | — | US | disclosed |
| WO-2018096088-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | UNIVERSITEIT ANTWERPEN (BE) | 2018-05-31 | — | — | WO | disclosed |
| EP-3180003-A1 | PKC-EPSILON INHIBITORS | The Regents of the University of California (US) | 2017-06-21 | — | — | EP | disclosed |
| EP-1907362-A1 | AMIDE DERIVATIVES AS KINASE INHIBITORS | Devgen NV (BE) | 2008-04-09 | — | — | EP | disclosed |
| EP-1907361-A1 | AMIDE DERIVATIVES AS KINASE INHIBITORS | Devgen N.V. (BE) | 2008-04-09 | — | — | EP | disclosed |
| US-20080039442-A1 | Compounds With Kv4 Ion Channel Activity | DEVGEN NV (BE) | 2008-02-14 | — | — | US | disclosed |
| WO-2007138112-A2 | COMPOUNDS THAT INTERACT WITH ION CHANNELS, IN PARTICULAR WITH ION CHANNELS FROM THE KV FAMILY | DEVGEN N.V. (BE) | 2007-12-06 | — | — | WO | disclosed |
| WO-2007138110-A2 | COMPOUNDS THAT INTERACT WITH ION CHANNELS, IN PARTICULAR WITH ION CHANNELS FROM THE KV FAMILY | DEVGEN N.V. (BE) | 2007-12-06 | — | — | WO | disclosed |
| EP-1819330-A1 | 5-CARBOXAMIDO SUBSTITUED THIAZOLE DERIVATIVES THAT INTERACT WITH ION CHANNELS, IN PARTICULAR WITH ION CHANNELS FROM THE KV FAMILY | Devgen N.V. (BE) | 2007-08-22 | — | — | EP | disclosed |
| WO-2007042321-A2 | KINASE INHIBITORS | DEVGEN N.V. (BE) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007006547-A1 | AMIDE DERIVATIVES AS KINASE INHIBITORS | DEVGEN N.V. (BE) | 2007-01-18 | — | — | WO | disclosed |
| WO-2007006546-A1 | AMIDE DERIVATIVES AS KINASE INHIBITORS | DEVGEN N.V. (BE) | 2007-01-18 | — | — | WO | disclosed |
| WO-2006058905-A1 | 5-CARBOXAMIDO SUBSTITUTED THIAZOLE DERIVATIVES THAT INTERACT WITH ION CHANNELS, IN PARTICULAR WITH ION CHANNELS FROM THE Kv FAMILY | DEVGEN NV (BE) | 2006-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190284130-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | ATG4B, ATG7, ATG4A | KDM4E 962/4885LMNA 3856/4885MMP2 3645/4885 |
| US-20080039442-A1 | Compounds With Kv4 Ion Channel Activity | KCNA4, HCN4, KCNN4 | KDM4E 618/4885LMNA 904/4885MMP2 2373/4885 |
| US-20210145838-A1 | SELECTIVE PDE4D INHIBITORS AGAINST DEMYELINATING DISEASES | PDE4A, PDE4D, PDE4B | KDM4E 290/4885LMNA 3077/4885MMP2 1484/4885 |
| US-10738002-B2 | Halogenated benzotropolones as ATG4B inhibitors | ATG4B, ATG7, BECN1 | KDM4E 1039/4885LMNA 3483/4885MMP2 3489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.