Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | EDNRB | P24530 | 4/20 | 0.33 |
| ▸ | EDNRA | P25101 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8056643 | 0.87 | EDNRA (0.43) | POLBMAPTEDNRBEDNRATP53 | |
| SCHEMBL6771344 | 0.81 | EDNRB (0.43) | EDNRBEDNRA | |
| SCHEMBL4632432 | 0.79 | MAPT (0.36) | POLBALDH1A1MAPTTP53GAA | |
| SCHEMBL6770903 | 0.78 | KEAP1 (0.40) | POLBKEAP1NFE2L2SMN1; SMN2ALDH1A1 | |
| SCHEMBL6772980 | 0.77 | EDNRB (0.41) | EDNRBEDNRA | |
| SCHEMBL7086343 | 0.76 | EDNRA (0.38) | SMN1; SMN2ALDH1A1MAPTEDNRATP53 | |
| SCHEMBL6772649 | 0.74 | TDP1 (0.34) | SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL6777054 | 0.73 | EDNRA (0.46) | EDNRA | |
| SCHEMBL6770897 | 0.73 | KEAP1 (0.41) | POLBKEAP1NFE2L2SMN1; SMN2ALDH1A1 | |
| SCHEMBL4632109 | 0.72 | EDNRB (0.43) | MAPTEDNRBEDNRATP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673824-B1 | HYPOTENSIVE AGENTS | BRISTOL-MYERS SQUIBB CO. | 2004-01-06 | — | — | US | disclosed |
| US-6107320-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | disclosed |
| US-5514696-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1996-05-07 | — | — | US | disclosed |