Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6772980 | 0.83 | EDNRB (0.41) | — | |
| SCHEMBL8056643 | 0.82 | EDNRA (0.43) | TDP1KMT2AHSD11B1 | |
| SCHEMBL6772653 | 0.81 | NPSR1 (0.35) | TDP1ALDH1A1 | |
| SCHEMBL6776263 | 0.78 | EDNRA (0.46) | — | |
| SCHEMBL7086343 | 0.77 | EDNRA (0.38) | TDP1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6772650 | 0.76 | TDP1 (0.34) | TDP1ALDH1A1MEN1KMT2AGHSR | |
| SCHEMBL6770893 | 0.74 | POLB (0.36) | ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4632432 | 0.72 | MAPT (0.36) | ALDH1A1MEN1KMT2A | |
| Bicarbonate SCHEMBL8501477 | 0.71 | EDNRB (0.39) | MEN1KMT2A | |
| SCHEMBL6771344 | 0.68 | EDNRB (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673824-B1 | HYPOTENSIVE AGENTS | BRISTOL-MYERS SQUIBB CO. | 2004-01-06 | — | — | US | disclosed |
| US-6107320-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | disclosed |