Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.43 |
| ▸ | EDNRB | P24530 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6770893 | 0.87 | POLB (0.36) | EDNRAEDNRBL3MBTL1MAPTTP53 | |
| SCHEMBL6772980 | 0.85 | EDNRB (0.41) | EDNRAEDNRB | |
| SCHEMBL6777477 | 0.84 | EDNRA (0.42) | EDNRAEDNRB | |
| SCHEMBL6772649 | 0.82 | TDP1 (0.34) | KMT2ATDP1HSD11B1 | |
| SCHEMBL4632432 | 0.81 | MAPT (0.36) | MAPTTP53KMT2APOLB | |
| SCHEMBL7086343 | 0.80 | EDNRA (0.38) | EDNRAMAPTTP53KMT2ATDP1 | |
| SCHEMBL4632109 | 0.79 | EDNRB (0.43) | EDNRAEDNRBMAPTTP53KMT2A | |
| SCHEMBL6777054 | 0.78 | EDNRA (0.46) | EDNRA | |
| SCHEMBL6776263 | 0.78 | EDNRA (0.46) | EDNRA | |
| SCHEMBL7956927 | 0.77 | EDNRA (0.43) | EDNRAEDNRBL3MBTL1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080774-A | Substituted biphenylsulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-06-27 | — | — | US | disclosed |
| EP-0768305-A1 | N-Isoxazolyl-biphenylsulfonamide derivatives, their preparation and their use as endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-16 | — | — | EP | disclosed |