Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 7/20 | 0.44 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 11/20 | 0.42 |
| ▸ | ITGAV | P06756 | 11/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.42 |
| ▸ | ITGB6 | P18564 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6768600 | 0.76 | HTT (0.50) | ITGB1ITGA5ITGB3ITGAVITGB5 | |
| SCHEMBL30449687 | 0.75 | CYP2C19 (0.59) | ITGB3ITGAVCYP2C19ALOX12CYP1A2 | |
| SCHEMBL515358 | 0.75 | CYP2C19 (0.59) | ITGB3ITGAVCYP2C19ALOX12CYP1A2 | |
| SCHEMBL15923432 | 0.74 | ALOX12 (0.52) | ITGB1ITGB3ITGAVITGB5ITGB6 | |
| SCHEMBL10606557 | 0.73 | ALOX12 (0.60) | CYP2C19ALOX12CYP1A2 | |
| SCHEMBL7447683 | 0.73 | ALOX12 (0.60) | CYP2C19ALOX12CYP1A2 | |
| SCHEMBL1573818 | 0.73 | ALOX12 (0.60) | CYP2C19ALOX12CYP1A2 | |
| SCHEMBL10607875 | 0.73 | ALOX12 (0.60) | CYP2C19ALOX12CYP1A2 | |
| SCHEMBL31066860 | 0.73 | ALOX12 (0.60) | CYP2C19ALOX12CYP1A2 | |
| SCHEMBL31066872 | 0.73 | ALOX12 (0.60) | CYP2C19ALOX12CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6833366-B1 | Dihydrostilbene alkanoic acid derivatives | PHARMACIA CORPORATION | 2004-12-21 | — | — | US | disclosed |
| US-6720315-B2 | FOR INHIBITING BONE RESORPTION, PERIODONTAL DISEASE, OSTEOPOROSIS, HUMORAL HYPERCALCEMIA OF MALIGNANCY, PAGET'S DISEASE, TUMOR METASTASIS, SOLID TUMOR GROWTH, ANGIOGENESIS, MACULAR DEGENERATION AND DIABETIC RETINOPATHY RETINOPATHY | PHARMACIA CORPORATION | 2004-04-13 | — | — | US | disclosed |
| EP-1289959-A1 | DIHYDROSTILBENE ALKANOIC ACID DERIVATIVES USEFUL AS VITRONECTIN ANTAGONISTS | Pharmacia Corporation (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096310-A1 | DIHYDROSTILBENE ALKANOIC ACID DERIVATIVES USEFUL AS VITRONECTIN ANTAGONISTS | PHARMACIA CORPORATION (US) | 2001-12-20 | — | — | WO | disclosed |