Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6473512 | 0.83 | PDE4B (0.42) | PDE4APDE4BPDE4CPDE4DRECQL | |
| SCHEMBL6483494 | 0.82 | RECQL (0.45) | PDE4APDE4BPDE4CPDE4DCSNK2A1 | |
| SCHEMBL6476199 | 0.76 | RECQL (0.45) | PDE4APDE4BPDE4CPDE4DCSNK2A1 | |
| SCHEMBL6481387 | 0.73 | PDE4B (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5309679 | 0.72 | PDE4B (0.56) | PDE4APDE4BPDE4CPDE4DCSNK2A1 | |
| SCHEMBL6775035 | 0.72 | TPH1 (0.47) | PDE4APDE4BPDE4CPDE4DRECQL | |
| SCHEMBL6774108 | 0.72 | RECQL (0.45) | PDE4APDE4BPDE4CPDE4DRECQL | |
| SCHEMBL2956981 | 0.72 | CSNK2A1 (0.66) | PDE4APDE4BPDE4CPDE4DCSNK2A1 | |
| SCHEMBL9276238 | 0.72 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DRECQL | |
| SCHEMBL6473525 | 0.71 | GAA (0.43) | PDE4APDE4BPDE4CPDE4DRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043324-B1 | PURINE DERIVATIVES AND MEDICINE CONTAINING THE SAME AS THE ACTIVE INGREDIENT | MITSUBISHI CHEM CORP (JP) | 2004-06-16 | — | — | EP | disclosed |
| US-6734187-B1 | ANTIASTHMATIC AGENTS | MITSUBISHI CHEMICAL CORPORATION (JP) | 2004-05-11 | — | — | US | disclosed |
| EP-1043324-A1 | PURINE DERIVATIVES AND MEDICINE CONTAINING THE SAME AS THE ACTIVE INGREDIENT | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-10-11 | — | — | EP | disclosed |