Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.60 |
| ▸ | HTR7 | P34969 | 4/20 | 0.58 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11246005 | 0.87 | SIGMAR1 (0.55) | TAAR1HTR7DPP4ADRB2ADRB1 | |
| SCHEMBL11060982 | 0.85 | CD274 (0.61) | TAAR1HTR7ADRB2ADRB1KDM4E | |
| Hydrochloric Acid SCHEMBL9952490 | 0.85 | SIGMAR1 (0.53) | TAAR1HTR7DPP4ADRB2ADRB1 | |
| SCHEMBL6048555 | 0.81 | SRC (0.52) | TAAR1HTR7HTR2AHTR2CHTR1A | |
| SCHEMBL11333152 | 0.80 | DPP4 (0.65) | HTR7DPP4ALDH1A1FOLH1PDCD1 | |
| Hydrochloric Acid SCHEMBL6048546 | 0.80 | SRC (0.51) | TAAR1HTR7HTR2AHTR2CHTR1A | |
| Hydrogen Sulfide SCHEMBL27761134 | 0.79 | HTR1A (0.49) | HTR7DPP4PDCD1CD274CA12 | |
| SCHEMBL3464186 | 0.79 | DPP4 (0.54) | TAAR1HTR7DPP4KDM4EALDH1A1 | |
| SCHEMBL6048510 | 0.79 | HTR2A (0.56) | TAAR1HTR7HTR2AHTR2CHTR1A | |
| Hydrochloric Acid SCHEMBL6048492 | 0.78 | HTR2A (0.55) | TAAR1HTR7HTR2AHTR2CHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6710080-B2 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2004-03-23 | — | — | US | claimed |
| JP-2003506426-A | — | — | 2003-02-18 | — | — | JP | claimed |
| US-20020198251-A1 | Substituted 2-dialkylaminoalkylbiphenyl derivatives | GRUENENTHAL GMBH (DE) | 2002-12-26 | — | — | US | claimed |
| CN-1379755-A | Substituted 2-Dialkylaminoalkylbiphenyl Derivatives | GRUENTHAL GMBH (DE) | 2002-11-13 | — | — | CN | claimed |
| EP-1202953-A2 | SUBSTITUTED 2-DIALKYLAMINOALKYLBIPHENYL DERIVATIVES | Grünenthal GmbH (DE) | 2002-05-08 | — | — | EP | claimed |
| WO-2001010816-A2 | SUBSTITUTED 2-DIALKYLAMINOALKYLBIPHENYL DERIVATIVES | Grünenthal GmbH (DE) | 2001-02-15 | — | — | WO | claimed |
| US-4473709-A | Pyrethroid intermediates and process | FMC CORPORATION (US) | 1984-09-25 | — | — | US | claimed |
| CN-1245376-C | Substituted 2-Dialkylaminoalkylbiphenyl Derivatives | GRUENTHAL GMBH (DE) | 2006-03-15 | — | — | CN | disclosed |
| US-6710080-B2 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2004-03-23 | — | — | US | disclosed |
| US-20020198251-A1 | Substituted 2-dialkylaminoalkylbiphenyl derivatives | GRUENENTHAL GMBH (DE) | 2002-12-26 | — | — | US | disclosed |
| CN-1379755-A | Substituted 2-Dialkylaminoalkylbiphenyl Derivatives | GRUENTHAL GMBH (DE) | 2002-11-13 | — | — | CN | disclosed |
| EP-1202953-A2 | SUBSTITUTED 2-DIALKYLAMINOALKYLBIPHENYL DERIVATIVES | Grünenthal GmbH (DE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001010816-A2 | SUBSTITUTED 2-DIALKYLAMINOALKYLBIPHENYL DERIVATIVES | Grünenthal GmbH (DE) | 2001-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020198251-A1 | Substituted 2-dialkylaminoalkylbiphenyl derivatives | LIPA, PKD1, PKD2 | TAAR1 3902/4885HTR7 501/4885DPP4 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.