Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.45 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9952490 | 0.98 | SIGMAR1 (0.53) | SIGMAR1HTR7KDM4ETAAR1DPP4 | |
| SCHEMBL6771706 | 0.87 | TAAR1 (0.60) | HTR7KDM4ETAAR1DPP4PDCD1 | |
| SCHEMBL9670821 | 0.82 | SIGMAR1 (0.63) | SIGMAR1TAAR1ALDH1A1 | |
| SCHEMBL12506252 | 0.80 | DPP4 (0.60) | HTR7DPP4PDCD1CD274ALDH1A1 | |
| SCHEMBL28237237 | 0.80 | TAAR1 (0.49) | SIGMAR1HTR7KDM4ETAAR1LSS | |
| Hydrochloric Acid SCHEMBL11264059 | 0.80 | SIGMAR1 (0.45) | SIGMAR1HTR7KDM4ETAAR1 | |
| SCHEMBL1026184 | 0.79 | PPARA (0.53) | DPP4PDCD1CD274 | |
| Hydrochloric Acid SCHEMBL11335929 | 0.79 | DPP4 (0.40) | SIGMAR1HTR7DPP4PDCD1CD274 | |
| SCHEMBL8521601 | 0.78 | LIPG (0.55) | DPP4 | |
| SCHEMBL251097 | 0.78 | LIPG (0.55) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015776-B1 | 1,1'-BIPHENYL-2-YL ALKYLAMINE DERIVATIVES, THEIR PRODUCTION AND CARDIOVASCULAR PREPARATIONS CONTAINING SAME | ELI LILLY AND COMPANY (US) | 1982-06-30 | — | — | EP | disclosed |
| US-4277471-A | 1,1-Biphenyl-2-yl alkylamines, formulations and antiarrhythmic treatment | ELI LILLY AND COMPANY (US) | 1981-07-07 | — | — | US | disclosed |
| EP-0015776-A1 | 1,1'-Biphenyl-2-yl alkylamine derivatives, their production and cardiovascular preparations containing same | ELI LILLY AND COMPANY (US) | 1980-09-17 | — | — | EP | disclosed |