Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 5/20 | 0.49 |
| ▸ | HTR6 | P50406 | 4/20 | 0.49 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | HTR5A | P47898 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17476286 | 0.98 | LMNA (0.50) | ADRB1HTR6HTR2AHTR1ADRD2 | |
| SCHEMBL13533073 | 0.90 | DRD2 (0.55) | ADRB1HTR6HTR2AHTR1ADRD2 | |
| SCHEMBL28241594 | 0.88 | DRD2 (0.49) | ADRB1HTR6HTR2AHTR1ADRD2 | |
| SCHEMBL21646391 | 0.86 | DRD2 (0.48) | ADRB1HTR6HTR2AHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL28808104 | 0.85 | DRD2 (0.47) | HTR6HTR1ADRD2HTR2CKDM4E | |
| SCHEMBL30659401 | 0.83 | DRD2 (0.43) | HTR6HTR1ADRD2DRD3ALDH1A1 | |
| SCHEMBL15311796 | 0.83 | DRD2 (0.43) | ADRB1HTR1ADRD2HSD17B10HTR2C | |
| SCHEMBL30047448 | 0.83 | DRD2 (0.43) | ADRB1HTR1ADRD2HSD17B10HTR2C | |
| SCHEMBL15311895 | 0.83 | DRD2 (0.46) | HTR6HTR2AHTR1ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL23403776 | 0.82 | DRD2 (0.43) | ADRB1HTR1ADRD2HSD17B10HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524839-B2 | Compounds, their use and preparation | BIOVITRUM AM (PUBL.) | 2009-04-28 | — | — | US | disclosed |
| US-7220765-B2 | Derivatives of 2-arylimino-2,3-dihydrothiazoles, their preparation processes and their therapeutic use | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (SCRAS) (FR) | 2007-05-22 | — | — | US | disclosed |
| CN-1155567-C | Antipsychotic indolyl derivatives | 惠氏公司 | 2004-06-30 | — | — | CN | disclosed |
| US-6689792-B2 | USEFUL FOR THE TREATMENT OF SCHIZOPHRENIA AND RELATED PSYCHOTIC DISORDERS SUCH AS PARKINSON'S DISEASE AND ALZHEIMER'S DISEASE | WYETH | 2004-02-10 | — | — | US | disclosed |
| US-20020035112-A1 | Antipsychotic indolyl derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-03-21 | — | — | US | disclosed |
| US-6310066-B1 | 1-(4-CHLORO-PHENOXY)-3-(4-(1H-INDOL-4-YL)-PIPERAZIN-1-YL)-PROPAN-2-OL FOR EXAMPLE | AMERICAN HOME PRODUCTS CORP. | 2001-10-30 | — | — | US | disclosed |
| CN-1307562-A | Antipsychotic indolyl derivatives | AMERICAN HOME PROD (US) | 2001-08-08 | — | — | CN | disclosed |
| EP-1076647-A2 | ANTIPSYCHOTIC INDOLYL DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-21 | — | — | EP | disclosed |
| WO-1999055672-A2 | ANTIPSYCHOTIC INDOLYL DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020035112-A1 | Antipsychotic indolyl derivatives | DRD4, HTR4, DBH | ADRB1 106/4885HTR6 30/4885HTR2A 55/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.