Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 14/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.36 |
| ▸ | PLA2G2F | Q9BZM2 | 2/20 | 0.36 |
| ▸ | PLA2G2E | Q9NZK7 | 2/20 | 0.36 |
| ▸ | PLA2G2D | Q9UNK4 | 2/20 | 0.36 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.36 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.36 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.36 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.36 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6888939 | 0.91 | TSPO (0.42) | PLA2G2APLA2G1B | |
| SCHEMBL6772666 | 0.90 | CTNNB1 (0.41) | CTNNB1PLA2G2A | |
| SCHEMBL6771899 | 0.90 | CTNNB1 (0.43) | CTNNB1PLA2G2APLA2G1BSMN1; SMN2PLA2G10 | |
| SCHEMBL6776025 | 0.89 | CTNNB1 (0.43) | CTNNB1PLA2G2APLA2G1BSMN1; SMN2PLA2G10 | |
| SCHEMBL7963737 | 0.88 | PLA2G2A (0.47) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL6774146 | 0.88 | CTNNB1 (0.49) | CTNNB1PLA2G2APLA2G1BSMN1; SMN2PLA2G10 | |
| SCHEMBL6772343 | 0.87 | CTNNB1 (0.40) | CTNNB1PLA2G2APLA2G1BSMN1; SMN2PLA2G10 | |
| SCHEMBL6775435 | 0.87 | PLA2G2A (0.40) | PLA2G2ASMN1; SMN2 | |
| SCHEMBL6776234 | 0.85 | PLA2G2A (0.47) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL6780594 | 0.85 | MEN1 (0.43) | PLA2G2APLA2G1BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |