Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6773208 | 0.91 | CTNNB1 (0.42) | PLA2G2APLA2G1B | |
| SCHEMBL6888714 | 0.91 | TSPO (0.39) | TSPOL3MBTL1LMNAMAPT | |
| SCHEMBL6891056 | 0.90 | TSPO (0.42) | TSPOKDM4EHSD17B10RAB9AMEN1 | |
| SCHEMBL6895266 | 0.90 | TSPO (0.42) | TSPOKDM4EHSD17B10PLA2G2ARAB9A | |
| SCHEMBL6889316 | 0.90 | TSPO (0.47) | TSPOKDM4EHSD17B10RAB9AMEN1 | |
| SCHEMBL6899176 | 0.88 | TSPO (0.41) | TSPOKDM4EHSD17B10RAB9AMEN1 | |
| SCHEMBL6896777 | 0.87 | FAAH (0.44) | KDM4EMEN1KMT2ALMNAMAPT | |
| SCHEMBL6894814 | 0.87 | MAPT (0.44) | KDM4EPLA2G2AMEN1KMT2ANPSR1 | |
| SCHEMBL6893122 | 0.86 | CCR8 (0.40) | TSPOKMT2AL3MBTL1P2RX3TDP1 | |
| SCHEMBL6897168 | 0.86 | PLA2G1B (0.44) | KDM4EHSD17B10PLA2G2AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |