Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 2/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5281106 | 0.83 | MAPT (0.62) | CRHBPCRHR2CYP1A2CYP2C9CYP2D6 | |
| SCHEMBL3423087 | 0.82 | CRHBP (0.57) | CRHBPCRHR2CYP1A2CYP2C9CYP2D6 | |
| SCHEMBL27378134 | 0.82 | CRHBP (0.51) | CRHBPCRHR2CYP1A2CYP2C9CYP2D6 | |
| SCHEMBL1131015 | 0.81 | CRHBP (0.58) | CRHBPCRHR2CYP1A2CYP2C9CYP2D6 | |
| SCHEMBL27559500 | 0.80 | CRHBP (0.55) | CRHBPCRHR2CYP1A2CYP2C9CYP2D6 | |
| SCHEMBL11107017 | 0.80 | ALDH1A1 (0.68) | CRHBPCRHR2CYP1A2CYP2C9CYP2D6 | |
| SCHEMBL38661270 | 0.80 | ALDH1A1 (0.46) | CRHBPCRHR2MAPTERN1LMNA | |
| SCHEMBL38660884 | 0.80 | ALDH1A1 (0.44) | MAPTERN1LMNAALDH1A1POLB | |
| SCHEMBL28886073 | 0.79 | ERN1 (0.57) | MAPTERN1LMNAALDH1A1POLB | |
| SCHEMBL27545137 | 0.79 | CRHBP (0.53) | CRHBPCRHR2CYP1A2CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6703387-B2 | STYRYLBENZODIAZEPINES | HOFFMANN-LA ROCHE INC. | 2004-03-09 | — | — | US | disclosed |
| EP-1299364-A1 | BENZODIAZEPINES AS INHIBITORS OF HPV E1 HELICASE | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-09 | — | — | EP | disclosed |
| US-20020128262-A1 | Inhibitors of HPV E1 helicase enzyme | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2002-09-12 | — | — | US | disclosed |
| WO-2002000632-A1 | BENZODIAZEPINES AS INHIBITORS OF HPV E1 HELICASE | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128262-A1 | Inhibitors of HPV E1 helicase enzyme | DHX15, DHX35, DHX36 | CRHBP 1724/4885CRHR2 2668/4885CYP1A2 445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.