Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 17/20 | 0.53 |
| ▸ | FPR3 | P25089 | 2/20 | 0.53 |
| ▸ | TSPO | P30536 | 2/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1636385 | 0.88 | CRHR1 (0.43) | CRHR1FPR3TSPOTMEM97 | |
| SCHEMBL14277045 | 0.88 | CRHR1 (0.43) | CRHR1FPR3TSPOTMEM97 | |
| SCHEMBL6214201 | 0.81 | FPR3 (0.38) | CRHR1FPR3TSPOTMEM97 | |
| SCHEMBL6214728 | 0.81 | FPR3 (0.37) | CRHR1FPR3TSPOTMEM97 | |
| SCHEMBL7619917 | 0.78 | CRHR1 (0.44) | CRHR1FPR3TSPOTMEM97 | |
| SCHEMBL6217815 | 0.77 | FPR3 (0.35) | CRHR1FPR3TSPOTMEM97 | |
| SCHEMBL27613787 | 0.76 | FPR3 (0.33) | CRHR1FPR3TSPOTMEM97 | |
| SCHEMBL7610604 | 0.76 | CRHR1 (0.82) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL6214712 | 0.76 | GABRB3 (0.35) | CRHR1FPR3TSPOTMEM97 | |
| SCHEMBL8122423 | 0.75 | CRHR1 (0.55) | CRHR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6765008-B1 | PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES; ANXIOLYTIC AGENTS; NERVOUS SYSTEM, BRAIN, PSYCHOLOGICAL, EATING, AND GASTROINTESTINAL DISORDERS; CORTICOTROPIN-RELEASING FACTOR ANTAGONISTS | PFIZER INC | 2004-07-20 | — | — | US | disclosed |
| US-6436932-B1 | PSYCHIATRIC DISORDERS AND NEUROLOGICAL DISEASES; CORTICOTROPIN RELEASING FACTOR; PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES | NEUROGEN CORPORATION | 2002-08-20 | — | — | US | disclosed |
| US-6310063-B1 | 4-PIPERAZINYL-3,6-DIMETHYL-1-(2,4,6-TRIMETHYLPHENYL)-PYRROLO(2,3 -B)PYRIDINE; TREATING ANXIETY, DEPRESSION, OR POST-TRAUMATIC STRESS DISORDER IN A MAMMAL; CORTICOTROPIN RELEASING FACTOR (CRF) RECEPTOR ANTAGONISTS | NEUROGEN CORPORATION | 2001-10-30 | — | — | US | disclosed |
| EP-0674641-B1 | PYRROLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 1999-03-03 | — | — | EP | disclosed |
| EP-0674641-A1 | PYRROLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013676-A1 | PYRROLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |