Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.61 |
| ▸ | MMP13 | P45452 | 14/20 | 0.61 |
| ▸ | MMP9 | P14780 | 13/20 | 0.61 |
| ▸ | MMP1 | P03956 | 12/20 | 0.61 |
| ▸ | MMP14 | P50281 | 2/20 | 0.53 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.53 |
| ▸ | MMP7 | P09237 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7394268 | 0.90 | ADAM17 (0.60) | ADAM17MMP13MMP9MMP1MMP14 | |
| SCHEMBL7396222 | 0.84 | ADAM17 (0.54) | ADAM17MMP13MMP9MMP1MMP14 | |
| SCHEMBL6508748 | 0.83 | MMP9 (0.79) | ADAM17MMP13MMP9MMP1MMP14 | |
| SCHEMBL6499431 | 0.81 | ADAM17 (0.59) | ADAM17MMP13MMP9MMP1MMP14 | |
| SCHEMBL6773805 | 0.80 | ADAM17 (0.57) | ADAM17MMP13MMP9MMP1MMP14 | |
| SCHEMBL7430744 | 0.80 | ADAM17 (0.52) | ADAM17MMP13MMP9MMP1MMP14 | |
| SCHEMBL6265979 | 0.77 | ADAM17 (0.60) | ADAM17MMP13MMP9MMP1MMP14 | |
| SCHEMBL3943916 | 0.76 | ADAM17 (1.00) | ADAM17MMP13MMP9MMP1MMP14 | |
| SCHEMBL6502069 | 0.76 | ADAM17 (0.78) | ADAM17MMP13MMP9MMP1MMP14 | |
| SCHEMBL7393438 | 0.76 | ADAM17 (0.66) | ADAM17MMP13MMP9MMP1MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6812227-B2 | SULFUR COMPOUNDS SUCH AS 2-((4-BUT-2-YNYLOXY-BENZENESULFONYL)-METHYL-AMINO)-N-HYDROXY-3-METHYL -BUTYRAMIDE, USED AS TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME (TACE) INHIBITORS, FOR PROPHYLAXIS OF RHEUMATIC DISEASES, SEPSIS OR INFLAMMATION | WYETH HOLDINGS CORPORATION | 2004-11-02 | — | — | US | disclosed |