Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 16/20 | 0.52 |
| ▸ | MMP13 | P45452 | 11/20 | 0.52 |
| ▸ | MMP2 | P08253 | 4/20 | 0.52 |
| ▸ | MMP1 | P03956 | 8/20 | 0.49 |
| ▸ | MMP9 | P14780 | 7/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.48 |
| ▸ | MMP14 | P50281 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7527426 | 0.83 | ADAM17 (0.49) | ADAM17MMP13MMP2MMP1MMP9 | |
| SCHEMBL6773809 | 0.80 | ADAM17 (0.61) | ADAM17MMP13MMP2MMP1MMP9 | |
| SCHEMBL7396222 | 0.74 | ADAM17 (0.54) | ADAM17MMP13MMP2MMP1MMP9 | |
| SCHEMBL6499431 | 0.73 | ADAM17 (0.59) | ADAM17MMP13MMP2MMP1MMP9 | |
| SCHEMBL6504827 | 0.73 | MMP13 (0.55) | ADAM17MMP13MMP2MMP1MMP9 | |
| SCHEMBL6508748 | 0.73 | MMP9 (0.79) | ADAM17MMP13MMP2MMP1MMP9 | |
| SCHEMBL7395509 | 0.72 | ADAM17 (0.56) | ADAM17MMP13MMP1MMP9MMP14 | |
| SCHEMBL6773805 | 0.72 | ADAM17 (0.57) | ADAM17MMP13MMP2MMP1MMP9 | |
| SCHEMBL6657607 | 0.71 | ADAM17 (0.79) | ADAM17MMP13MMP2MMP1MMP9 | |
| SCHEMBL6656562 | 0.71 | ADAM17 (0.66) | ADAM17MMP13MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144368-A2 | ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000044709-A2 | ACETYLENIC α-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |