Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 4/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.50 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1613999 | 0.82 | HTR4 (0.47) | EHMT2KDM4EHTR4ACHE | |
| SCHEMBL6406771 | 0.79 | HTR4 (0.50) | KDM4EHTR4ACHE | |
| SCHEMBL6336768 | 0.78 | HTR4 (0.62) | EHMT2HTR4GLACYP3A4ACHE | |
| SCHEMBL8801798 | 0.77 | HTR4 (0.64) | HTR4GLACYP3A4ACHE | |
| SCHEMBL3373962 | 0.77 | KDM4E (0.69) | KDM4EHTR4CYP3A4 | |
| SCHEMBL5500188 | 0.75 | KDM4E (0.55) | KDM4EHTR4CYP3A4 | |
| SCHEMBL8803953 | 0.74 | HTR4 (0.60) | CHRNB4CHRNA3CHRNB2CHRNA4HTR4 | |
| SCHEMBL26651130 | 0.72 | KDM4E (0.62) | KDM4EHTR4ACHE | |
| SCHEMBL3534600 | 0.72 | LMNA (0.51) | KDM4EHTR4CYP3A4 | |
| SCHEMBL6442660 | 0.72 | LMNA (0.51) | KDM4EHTR4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806274-B1 | IMMUNOREGULATION OR IMMUNOSUPPRESSIVE AGENTS; TYROSINE KINASE INHIBITORS; PREVENTING ORGAN TRANSPLANT REJECTION; AUTOIMMUNE CONDITIONS; REDUCED SIDE EFFECTS | ASTRAZENECA UK LIMITED (GB) | 2004-10-19 | — | — | US | disclosed |