Pnu-282987

Pnu-282987

SCHEMBL677422

O=C(N[C@H]1CN2CCC1CC2)c1ccc(Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 10/20 1.00
HTR3E A5X5Y0 4/20 1.00
HTR3B O95264 4/20 1.00
HTR3A P46098 4/20 1.00
HTR3D Q70Z44 4/20 1.00
HTR3C Q8WXA8 4/20 1.00
ALOX15 P16050 1/20 1.00
TSHR P16473 1/20 1.00
ALDH1A1 P00352 1/20 0.60
MEN1 O00255 1/20 0.59
KMT2A Q03164 1/20 0.59
ATM Q13315 1/20 0.59
CHRNB4 P30926 2/20 0.58
CHRNA3 P32297 2/20 0.58
CYP2D6 P10635 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pnu-282987 SCHEMBL6208420 1.00 CHRNA7 (1.00) CHRNA7HTR3EHTR3BHTR3AHTR3D
Pnu-282987 SCHEMBL10436185 1.00 CHRNA7 (1.00) CHRNA7HTR3EHTR3BHTR3AHTR3D
Pnu-282987 SCHEMBL9601902 0.99 CHRNA7 (0.97) CHRNA7HTR3EHTR3BHTR3AHTR3D
Pnu-282987 SCHEMBL1118980 0.99 CHRNA7 (0.97) CHRNA7HTR3EHTR3BHTR3AHTR3D
Pnu-282987 SCHEMBL7281159 0.99 CHRNA7 (0.97) CHRNA7HTR3EHTR3BHTR3AHTR3D
SCHEMBL6209105 0.93 CHRNA7 (0.86) CHRNA7HTR3EHTR3BHTR3AHTR3D
Pnu-282987 SCHEMBL5598576 0.92 CHRNA7 (0.85) CHRNA7HTR3EHTR3BHTR3AHTR3D
Pnu-282987 SCHEMBL5598573 0.92 CHRNA7 (0.85) CHRNA7HTR3EHTR3BHTR3AHTR3D
SCHEMBL373483 0.92 CHRNA7 (0.85) CHRNA7HTR3EHTR3BHTR3AHTR3D
SCHEMBL372855 0.92 CHRNA7 (0.85) CHRNA7HTR3EHTR3BHTR3AHTR3D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 137 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230346879-A1 COMPOSITIONS AND METHODS FOR COMBINATORIAL DRUG DISCOVERY IN NANOLITER DROPLETS MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2023-11-02 US claimed
US-20220117989-A1 COMPOSITIONS AND METHODS FOR INDUCING OR SUPPLEMENTING SOCS3 TO ABROGATE TUMOR GROWTH AND PROLIFERATIVE RETINOPATHY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-04-21 US claimed
US-20210145818-A1 COMPOSITIONS INFUSED WITH NICOTINE COMPOUNDS AND METHODS OF USE THEREOF Poviva Corp. 2021-05-20 US claimed
EP-3781163-A1 COMPOSITIONS INFUSED WITH NICOTINE COMPOUNDS AND METHODS OF USE THEREOF Poviva Corp. (US) 2021-02-24 EP claimed
EP-3284467-B1 NICOTINE-CONTAINING PHARMACEUTICAL COMPOSITIONS NICONOVUM USA INC (US) 2019-10-30 EP claimed
WO-2019202396-A1 COMPOSITIONS INFUSED WITH NICOTINE COMPOUNDS AND METHODS OF USE THEREOF POVIVA TEA, LLC (US) 2019-10-24 WO claimed
EP-3284467-A1 NICOTINE-CONTAINING PHARMACEUTICAL COMPOSITIONS Niconovum USA, Inc. (US) 2018-02-21 EP claimed
EP-2566476-B1 NICOTINE-CONTAINING PHARMACEUTICAL COMPOSITIONS NICONOVUM USA INC (US) 2017-11-22 EP claimed
US-20170326138-A1 NICOTINE-CONTAINING PHARMACEUTICAL COMPOSITIONS NICONOVUM USA, INC. (US) 2017-11-16 US claimed
US-20170273957-A1 ANTITUSSIVE COMPOSITIONS AND METHODS ATTENUA, INC. 2017-09-28 US claimed
EP-1863485-A2 ALPHA7 NEURONAL NICOTINIC RECEPTOR LIGAND AND ANTIPSYCHOTIC COMPOSITIONS ABBOTT LABORATORIES (US) 2007-12-12 EP claimed
WO-2006101745-A2 ALPHA7 NEURONAL NICOTINIC RECEPTOR LIGAND AND ANTIPSYCHOTIC COMPOSITIONS ABBOTT LABORATORIES (US) 2006-09-28 WO claimed
US-20060211686-A1 Alpha7 Neuronal nicotinic receptor ligand and antipsychotic compositions ABBOTT LABORATORIES 2006-09-21 US claimed
US-20060019984-A1 Treatment of diseases with alpha-7nACh receptor full agonists PFIZER INC 2006-01-26 US claimed
US-20050245504-A1 Treatment of diseases with combinations of alpha 7 Nicotinic Acetylcholine Receptor agonists and other compounds CORBETT JEFFREY W 2005-11-03 US claimed
EP-1572205-A2 TREATMENT OF DISEASES WITH COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS AND OTHER COMPOUNDS Pharmacia & Upjohn Company LLC (US) 2005-09-14 EP claimed
EP-1572300-A1 COMBINATION FOR THE TREATMENT OF ADHD Pharmacia & Upjohn Company LLC (US) 2005-09-14 EP claimed
US-20050107425-A1 Treatment of attention defecit hyperactivity disorder PFIZER INC 2005-05-19 US claimed
WO-2004052461-A1 COMBINATION FOR THE TREATMENT OF ADHD PHARMACIA & UPJOHN COMPANY LLC (US) 2004-06-24 WO claimed
WO-2004052348-A2 TREATMENT OF DISEASES WITH COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS AND OTHER COMPOUNDS PHARMACIA & UPJOHN COMPANY LLC (US) 2004-06-24 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230346879-A1 COMPOSITIONS AND METHODS FOR COMBINATORIAL DRUG DISCOVERY IN NANOLITER DROPLETS RAB5IF, CLTB, TBK1 CHRNA7 4663/4885HTR3E 4324/4885HTR3B 4317/4885
US-20050245504-A1 Treatment of diseases with combinations of alpha 7 Nicotinic Acetylcholine Receptor agonists and other compounds CHRNA7, CHRNG, CHRNE CHRNA7 1/4885HTR3E 673/4885HTR3B 326/4885
US-20170273957-A1 ANTITUSSIVE COMPOSITIONS AND METHODS CHRNA7, CHRNA1, CHRNG CHRNA7 1/4885HTR3E 235/4885HTR3B 93/4885
US-20060019984-A1 Treatment of diseases with alpha-7nACh receptor full agonists CHRNA7, CHRNA1, CHRNG CHRNA7 1/4885HTR3E 837/4885HTR3B 334/4885
US-20060211686-A1 Alpha7 Neuronal nicotinic receptor ligand and antipsychotic compositions CHRNA7, CHRNA5, CHRNA6 CHRNA7 1/4885HTR3E 182/4885HTR3B 87/4885
US-20210145818-A1 COMPOSITIONS INFUSED WITH NICOTINE COMPOUNDS AND METHODS OF USE THEREOF CHRNA5, SLC18A3, CHRNA6 CHRNA7 12/4885HTR3E 320/4885HTR3B 232/4885
US-20220117989-A1 COMPOSITIONS AND METHODS FOR INDUCING OR SUPPLEMENTING SOCS3 TO ABROGATE TUMOR GROWTH AND PROLIFERATIVE RETINOPATHY EYA3, RB1, ALDH1A2 CHRNA7 323/4885HTR3E 1566/4885HTR3B 2296/4885
US-20050107425-A1 Treatment of attention defecit hyperactivity disorder CHRNA7, CHRNA10, SLC18A3 CHRNA7 1/4885HTR3E 45/4885HTR3B 33/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.