Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GRK6 | P43250 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.34 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.34 |
| ▸ | GYS1 | P13807 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.33 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615522 | 0.83 | POLB (0.34) | POLBKMT2AMEN1PTGDR2HPGD | |
| SCHEMBL6617690 | 0.83 | GRM5 (0.34) | GRK6KMT2AMEN1PTGDR2USP2 | |
| SCHEMBL6618060 | 0.79 | MTNR1B (0.41) | GRK6KMT2AMEN1USP2KDM4E | |
| SCHEMBL6616467 | 0.75 | L3MBTL1 (0.40) | KMT2AMEN1KDM4EALDH1A1GAA | |
| SCHEMBL6673844 | 0.74 | TP53 (0.44) | KMT2AUSP2KDM4EALDH1A1GAA | |
| SCHEMBL6617013 | 0.73 | CA1 (0.40) | POLBKMT2AMEN1GYS1TSHR | |
| SCHEMBL6616704 | 0.73 | KDM4E (0.41) | POLBGRK6KMT2AMEN1KDM4E | |
| SCHEMBL6773561 | 0.69 | MAPT (0.48) | KMT2AMEN1KDM4EALDH1A1GAA | |
| SCHEMBL6617970 | 0.65 | PRCP (0.44) | KDM4EALDH1A1GAASMN1; SMN2HSD17B10 | |
| SCHEMBL6616789 | 0.63 | TGFBR1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040010027-A1 | Hydroxphenyl-pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical comositions comprising them | PHARMACIA & UPJOHN SPA (IT) | 2004-01-15 | — | — | US | claimed |
| US-20040010027-A1 | Hydroxphenyl-pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical comositions comprising them | PHARMACIA & UPJOHN SPA (IT) | 2004-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040010027-A1 | Hydroxphenyl-pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical comositions comprising them | CNKSR1, CSNK1A1, CDK6 | POLB 3561/4885GRK6 10/4885KMT2A 2713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.