Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10458447 | 0.68 | KDM4E (0.72) | KDM4ERAB9AHTTMAPTPOLB | |
| SCHEMBL6880333 | 0.67 | EGFR (0.38) | KDM4EKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL6774600 | 0.66 | KDM4E (0.50) | KDM4ERAB9AHTTMAPTPOLB | |
| SCHEMBL6774589 | 0.65 | KDM4E (0.49) | KDM4ERAB9AHTTMAPTPOLB | |
| SCHEMBL30763135 | 0.65 | MCL1 (0.66) | KDM4ERAB9AHTTPOLBSMN1; SMN2 | |
| SCHEMBL9901399 | 0.65 | MCL1 (0.66) | KDM4ERAB9AHTTPOLBSMN1; SMN2 | |
| SCHEMBL5553023 | 0.64 | HTT (0.47) | KDM4ERAB9AHTTMAPTSMN1; SMN2 | |
| SCHEMBL11449284 | 0.64 | CYP1A2 (0.65) | KDM4ERAB9AHTTMAPTPOLB | |
| SCHEMBL11563061 | 0.62 | CYP1A2 (0.58) | KDM4ERAB9AHTTMAPTPOLB | |
| SCHEMBL22926342 | 0.62 | HTT (1.00) | KDM4ERAB9AHTTMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806274-B1 | IMMUNOREGULATION OR IMMUNOSUPPRESSIVE AGENTS; TYROSINE KINASE INHIBITORS; PREVENTING ORGAN TRANSPLANT REJECTION; AUTOIMMUNE CONDITIONS; REDUCED SIDE EFFECTS | ASTRAZENECA UK LIMITED (GB) | 2004-10-19 | — | — | US | disclosed |