Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 3/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.43 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6774600 | 0.80 | KDM4E (0.50) | KDM4ERAB9AMAPTHTTPOLB | |
| SCHEMBL4686972 | 0.72 | HTT (0.48) | KDM4ERAB9AMAPTHTTPOLB | |
| SCHEMBL4686975 | 0.71 | PAK1 (0.62) | KDM4ERAB9AMAPTHTTSMN1; SMN2 | |
| SCHEMBL10458447 | 0.71 | KDM4E (0.72) | KDM4ERAB9AMAPTHTTPOLB | |
| SCHEMBL6774592 | 0.68 | MAPT (0.51) | KDM4ERAB9AMAPTHTTPOLB | |
| SCHEMBL3297016 | 0.66 | BRD4 (0.60) | RAB9AHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6774596 | 0.65 | KDM4E (0.47) | KDM4ERAB9AMAPTHTTPOLB | |
| SCHEMBL22926342 | 0.65 | HTT (1.00) | KDM4ERAB9AMAPTHTTPOLB | |
| SCHEMBL10540658 | 0.64 | MEN1 (0.61) | KDM4ERAB9AMAPTHTTPOLB | |
| SCHEMBL24449161 | 0.64 | CYP1A2 (0.77) | KDM4ERAB9AMAPTHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806274-B1 | IMMUNOREGULATION OR IMMUNOSUPPRESSIVE AGENTS; TYROSINE KINASE INHIBITORS; PREVENTING ORGAN TRANSPLANT REJECTION; AUTOIMMUNE CONDITIONS; REDUCED SIDE EFFECTS | ASTRAZENECA UK LIMITED (GB) | 2004-10-19 | — | — | US | disclosed |