Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3366323 | 0.82 | HDAC1 (0.42) | MAPTALDH1A1HDAC1HDAC2HDAC3 | |
| SCHEMBL2911694 | 0.82 | HDAC1 (0.42) | MAPTALDH1A1HDAC1HDAC2HDAC3 | |
| SCHEMBL27476060 | 0.81 | HDAC3 (0.35) | MAPTALDH1A1HDAC1HDAC2HDAC3 | |
| SCHEMBL25333055 | 0.80 | ALDH1A1 (0.42) | MAPTALDH1A1HDAC1HDAC2HDAC3 | |
| SCHEMBL11300447 | 0.77 | ALDH1A1 (0.41) | MAPTALDH1A1HDAC1HDAC2HDAC3 | |
| SCHEMBL1516230 | 0.76 | LTA4H (0.47) | ALDH1A1LMNAHTTHPGD | |
| SCHEMBL2940229 | 0.75 | MEN1 (0.42) | MAPTALDH1A1PTGS1PTGS2MEN1 | |
| SCHEMBL11672538 | 0.74 | LTA4H (0.46) | ALDH1A1LMNAHTTSMN1; SMN2KCNH2 | |
| SCHEMBL14627814 | 0.74 | HDAC3 (0.55) | MAPTALDH1A1HDAC1HDAC2HDAC3 | |
| SCHEMBL3523840 | 0.74 | LTA4H (0.46) | ALDH1A1LMNAHTTSMN1; SMN2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677382-B1 | HALOGENATED OXYAMINES, USED AS ENZYME INHIBITORS FOR PROPHYLAXIS OF ATHEROSCLEROSIS AND CARDIOVASCULAR DISORDERS, AND AS ANTILIPEMIC AGENTS | PHARMACIA CORPORATION | 2004-01-13 | — | — | US | disclosed |
| US-6451830-B1 | Use of substituted N,N-disubstituted non-fused heterocyclo amino compounds for inhibiting cholesteryl ester transfer protein activity | G.D. SEARLE & CO. | 2002-09-17 | — | — | US | disclosed |