Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.40 |
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6776178 | 0.75 | MAOA (0.56) | MAOAMAOBCYP1A2CYP3A4TSHR | |
| SCHEMBL7265998 | 0.73 | CCNE2 (0.41) | MAOAMAOBMEN1KMT2ACYP1A2 | |
| SCHEMBL6774511 | 0.68 | MAOA (0.46) | MAOAMAOBMEN1KMT2ACYP3A4 | |
| SCHEMBL8280623 | 0.66 | MAOA (0.61) | MAOAMAOBCYP3A4TSHRELANE | |
| SCHEMBL1649965 | 0.66 | MAOA (0.44) | MAOAMAOBMEN1KMT2ACYP3A4 | |
| SCHEMBL6775253 | 0.66 | MAOA (0.44) | MAOAMAOBMEN1KMT2ACYP1A2 | |
| SCHEMBL5780263 | 0.65 | PDE3B (0.42) | MEN1KMT2ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL20618218 | 0.65 | MAOA (0.77) | MAOAMAOBMEN1KMT2ACYP1A2 | |
| SCHEMBL8417659 | 0.65 | MAOA (0.86) | MAOAMAOBMEN1KMT2ACYP3A4 | |
| SCHEMBL31112247 | 0.65 | MAOA (0.77) | MAOAMAOBMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6680326-B2 | ANTITUMOR AGENTS; ANTICANCER AGENTS | HOFFMANN-LA ROCHE INC. | 2004-01-20 | — | — | US | disclosed |