Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 8/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 8/20 | 0.42 |
| ▸ | RELA | Q04206 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28137295 | 0.93 | CYP1A2 (0.60) | CYP1A2CYP2D6CYP2C9CYP2C19HIF1A | |
| SCHEMBL28217691 | 0.77 | CYP1A2 (0.46) | CYP1A2CYP2D6CYP2C9CYP2C19HIF1A | |
| SCHEMBL1514531 | 0.77 | CYP1A2 (0.53) | CYP1A2CYP2D6CYP2C9CYP2C19HIF1A | |
| SCHEMBL2791039 | 0.75 | CYP1A2 (0.54) | CYP1A2CYP2D6CYP2C9CYP2C19HIF1A | |
| SCHEMBL27944935 | 0.73 | CYP1A2 (0.50) | CYP1A2CYP2D6CYP2C9CYP2C19HIF1A | |
| SCHEMBL10876813 | 0.73 | CYP1A2 (0.46) | CYP1A2CYP2D6CYP2C9CYP2C19HIF1A | |
| SCHEMBL6944904 | 0.73 | CYP1A2 (0.51) | CYP1A2CYP2D6CYP2C9CYP2C19HIF1A | |
| SCHEMBL29568643 | 0.71 | CYP1A2 (0.47) | CYP1A2CYP2D6CYP2C9CYP2C19HIF1A | |
| SCHEMBL901095 | 0.71 | CYP1A2 (0.47) | CYP1A2CYP2D6CYP2C9CYP2C19HIF1A | |
| SCHEMBL7901109 | 0.71 | CYP1A2 (0.47) | CYP1A2CYP2D6CYP2C9CYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6747032-B2 | DOUBLE ALPHA 2/5-HT 2C ANTAGONISTS USED TO TREAT DEPRESSION, IMPULSIVE BEHAVIOUR DISORDERS, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, COGNITIVE DISORDERS AND DISORDERS INVOLVING SEXUAL FUNCTION, SLEEP AND EATING | LES LABORATOIRES SERVIER (FR) | 2004-06-08 | — | — | US | disclosed |
| US-20030087916-A1 | Pyrimidin-4-one compounds | LES LABORATOIRES SERVIER (FR) | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087916-A1 | Pyrimidin-4-one compounds | HTR2C, HTR1A, HTR4 | CYP1A2 75/4885CYP2D6 119/4885CYP2C9 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.