Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 13/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22703882 | 0.88 | TSHR (0.43) | ALDH1A1MAPTSMN1; SMN2KDM4EGLA | |
| SCHEMBL6361867 | 0.84 | KMT2A (0.49) | ALDH1A1MAPTSMN1; SMN2LMNARXFP1 | |
| SCHEMBL6621875 | 0.83 | MKNK1 (0.43) | HTTTDP1LMNAMAPK1RXFP1 | |
| SCHEMBL23525777 | 0.82 | ALDH1A1 (0.46) | ALDH1A1HTTTDP1MAPTSMN1; SMN2 | |
| SCHEMBL6782766 | 0.80 | ALDH1A1 (0.43) | ALDH1A1HTTTDP1MAPTSMN1; SMN2 | |
| SCHEMBL215798 | 0.77 | OPRK1 (0.47) | OPRK1ALDH1A1LMNAKDM4EGLA | |
| SCHEMBL8091281 | 0.77 | OPRK1 (0.47) | OPRK1ALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL28403320 | 0.77 | OPRK1 (0.47) | OPRK1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL14548784 | 0.76 | OPRK1 (0.44) | OPRK1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL1505507 | 0.76 | OPRK1 (0.46) | OPRK1ALDH1A1KDM4EGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756373-B1 | SUCH AS 5-(2-BUTOXY-5-IODO-3-PYRIDINYL)-3-ETHYL-2-(2-METHOXY-ETHYL)-2,6-DIHYDRO-7H -PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE; CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS; ERECTILE DYSFUNCTION | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |
| EP-1222190-A1 | 5-(2-SUBSTITUTED-5-HETEROCYCLYLSULPHONYLPYRID-3-YL)-DIHYDROPYRAZOLO[4,3-D]PYRIMIDIN-7-ONES AS PHOSPHODIESTERASE INHIBITORS | Pfizer Limited (GB) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001027112-A1 | 5-(2-SUBSTITUTED-5-HETEROCYCLYLSULPHONYLPYRID-3-YL)-DIHYDROPYRAZOLO[4,3-D]PYRIMIDIN-7-ONES AS PHOSPHODIESTERASE INHIBITORS | PFIZER LIMITED (GB) | 2001-04-19 | — | — | WO | disclosed |