Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ICMT | O60725 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PNLIP | P16233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6776025 | 0.94 | CTNNB1 (0.43) | CTNNB1PLA2G2APTGDR2BRD4SYK | |
| SCHEMBL6893122 | 0.90 | CCR8 (0.40) | CCR8KCNH2PPARAPTGDR2ALDH1A1 | |
| SCHEMBL7969644 | 0.89 | PLA2G2A (0.46) | PLA2G2APLA2G1B | |
| SCHEMBL6774857 | 0.86 | FAAH (0.43) | CCR8KCNH2PPARAPLA2G2AICMT | |
| SCHEMBL6777226 | 0.86 | ADRA1D (0.43) | PLA2G2AALDH1A1L3MBTL1GAA | |
| SCHEMBL6774146 | 0.86 | CTNNB1 (0.49) | CTNNB1PLA2G2APTGDR2ALDH1A1L3MBTL1 | |
| SCHEMBL27526328 | 0.85 | CCR8 (0.39) | CCR8KCNH2CTNNB1PPARAPLA2G2A | |
| SCHEMBL6775902 | 0.85 | PLA2G2A (0.42) | PLA2G2APTGDR2PLA2G1B | |
| SCHEMBL6771899 | 0.85 | CTNNB1 (0.43) | CTNNB1PLA2G2APTGDR2BRD4SYK | |
| SCHEMBL6690216 | 0.85 | PLA2G2A (0.43) | PLA2G2AALDH1A1L3MBTL1PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |