SCHEMBL677606

SCHEMBL677606

NC(Cc1ccc(Oc2cc(I)c(O)c(I)c2)cc1)C(=O)O

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.74
KMT2A Q03164 5/20 0.74
PPARG P37231 4/20 0.74
NR1I2 O75469 2/20 0.74
AGTR2 P50052 1/20 0.74
BLM P54132 1/20 0.74
THRB P10828 9/20 0.71
THRA P10827 6/20 0.71
LMNA P02545 4/20 0.71
ADORA3 P0DMS8 3/20 0.71
HSD17B10 Q99714 3/20 0.71
TTR P02766 2/20 0.71
PDE4D Q08499 2/20 0.71
USP2 O75604 2/20 0.71
ALOX15 P16050 2/20 0.71
PTGS2 P35354 2/20 0.71
NR3C1 P04150 1/20 0.71
CYP1A2 P05177 1/20 0.71
HTR1A P08908 1/20 0.71
CYP2C9 P11712 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2139921 1.00 MEN1 (0.74) MEN1KMT2APPARGNR1I2AGTR2
SCHEMBL9619480 1.00 MEN1 (0.74) MEN1KMT2APPARGNR1I2AGTR2
SCHEMBL29651864 0.88 THRB (0.77) MEN1KMT2APPARGNR1I2AGTR2
SCHEMBL677617 0.88 THRB (0.77) MEN1KMT2APPARGNR1I2AGTR2
SCHEMBL1170063 0.88 THRB (0.77) MEN1KMT2APPARGNR1I2AGTR2
SCHEMBL29135014 0.88 THRB (0.77) MEN1KMT2APPARGNR1I2AGTR2
SCHEMBL14576177 0.87 MEN1 (0.84) MEN1KMT2APPARGNR1I2AGTR2
SCHEMBL14576176 0.87 MEN1 (0.84) MEN1KMT2APPARGNR1I2AGTR2
SCHEMBL12866362 0.86 MEN1 (0.57) MEN1KMT2APPARGNR1I2AGTR2
Reverse Triiodothyronine SCHEMBL93385 0.85 MEN1 (1.00) MEN1KMT2APPARGNR1I2AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114609266-B Application of marker in preparation of diagnostic reagent for thyroid related diseases 徐州医科大学 2023-03-24 CN claimed
CN-114609265-B Method for detecting eight thyroid hormone markers in serum by liquid chromatography tandem mass spectrometry technology 徐州医科大学 2023-01-24 CN claimed
US-20200222348-A1 BIMODAL MODIFIED RELEASE COMPOSITIONS FOR CANCER TREATMENT MUSLI THYROPEUTICS LTD. (IL) 2020-07-16 US claimed
EP-1992341-A1 New pharmaceutical compositions comprising a thyroid hormon and their therapeutic use Université Joseph Fourier (FR) 2008-11-19 EP claimed
EP-0093653-B1 PROCESS FOR THE PREPARATION OF IODO-THYRONINES AND IODO-THYROACETIC ACIDS BY ELECTROCHEMICAL REDUCTION AT A CONTROLLED POTENTIAL SPIRAL Société à responsabilité limitée dite : (FR) 1985-07-10 EP claimed
US-4490221-A Process for preparing iodothyronines and iodothyroacetic acids by electrochemical reduction at controlled potential SPIRAL SOCIETE A RESPONSABILITE LIMITEE DITE (FR) 1984-12-25 US claimed
EP-4733383-A1 CULTURE MEDIUM AND BLOOD CELL CLONE, AND METHOD FOR PRODUCING SAME Japan Institute for Health Security (JP) 2026-04-29 EP disclosed
WO-2024262610-A1 CULTURE MEDIUM AND BLOOD CELL CLONE, AND METHOD FOR PRODUCING SAME 国立研究開発法人国立国際医療研究センター 2024-12-26 WO disclosed
CN-114609266-B Application of marker in preparation of diagnostic reagent for thyroid related diseases 徐州医科大学 2023-03-24 CN disclosed
CN-114609265-B Method for detecting eight thyroid hormone markers in serum by liquid chromatography tandem mass spectrometry technology 徐州医科大学 2023-01-24 CN disclosed
CN-112246221-B Polyion liquid covalent organic framework material, preparation method and application thereof 徐州医科大学 2023-01-20 CN disclosed
CN-112246221-A Polyion liquid covalent organic framework material, preparation method and application thereof 徐州医科大学 2021-01-22 CN disclosed
US-20200222348-A1 BIMODAL MODIFIED RELEASE COMPOSITIONS FOR CANCER TREATMENT MUSLI THYROPEUTICS LTD. (IL) 2020-07-16 US disclosed
US-20090221014-A1 Enzymatic Biosensors With Enhanced Activity Retention For Detection Of Organic Compounds COLORADO STATE UNIVERSITY RESEARCH FOUNDATION 2009-09-03 US disclosed
EP-2068859-A1 NEW PHARMACEUTICAL COMPOSITIONS COMPRISING A THYROID HORMON AND THEIR THERAPEUTIC USE Université Joseph Fourier (FR) 2009-06-17 EP disclosed
US-20090026092-A1 Enzymatic Biosensors With Enhanced Activity Retention For Detection Of Organic Compounds NIH - DEITR 2009-01-29 US disclosed
WO-2008138995-A1 NEW PHARMACEUTICAL COMPOSITIONS COMPRISING A THYROID HORMON AND THEIR THERAPEUTIC USE UNIVERSITE JOSEPH FOURIER (FR) 2008-11-20 WO disclosed
EP-1992341-A1 New pharmaceutical compositions comprising a thyroid hormon and their therapeutic use Université Joseph Fourier (FR) 2008-11-19 EP disclosed
US-7381538-B2 Optical biosensor with enhanced activity retention for detection of halogenated organic compounds COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (CSURF) (US) 2008-06-03 US disclosed
US-4490221-A Process for preparing iodothyronines and iodothyroacetic acids by electrochemical reduction at controlled potential SPIRAL SOCIETE A RESPONSABILITE LIMITEE DITE (FR) 1984-12-25 US disclosed