Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 10/20 | 0.58 |
| ▸ | HTR3A | P46098 | 4/20 | 0.58 |
| ▸ | HTR2C | P28335 | 4/20 | 0.58 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.58 |
| ▸ | HTR3B | O95264 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.58 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.57 |
| ▸ | HTR1D | P28221 | 3/20 | 0.57 |
| ▸ | HTR2B | P41595 | 3/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501132 | 0.89 | HTR4 (0.51) | HTR4HTR3AHTR2CHTR3EHTR3B | |
| SCHEMBL7360905 | 0.84 | HTR4 (0.81) | HTR4HTR3AHTR2CHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL6776352 | 0.83 | HTR2C (0.82) | HTR4HTR3AHTR2CHTR3EHTR3B | |
| SCHEMBL6771956 | 0.81 | HTR4 (0.63) | HTR4HTR3AHTR2CHTR3EHTR3B | |
| SCHEMBL7888555 | 0.80 | HTR4 (0.60) | HTR4HTR3AHTR2CHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL7248493 | 0.78 | HTR2C (0.79) | HTR4HTR3AHTR2CHTR3EHTR3B | |
| SCHEMBL7052002 | 0.75 | HTR4 (0.56) | HTR4HTR3AHTR2CHTR3EHTR3B | |
| SCHEMBL8686062 | 0.75 | HTR4 (0.52) | HTR4HTR3AHTR2CHTR3EHTR3B | |
| SCHEMBL8828815 | 0.75 | HTR4 (0.52) | HTR4HTR3AHTR2CHTR3EHTR3B | |
| SCHEMBL8828822 | 0.75 | HTR4 (0.52) | HTR4HTR3AHTR2CHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6800628-B2 | SUCH AS (1-(2-((3-METHYL-2-PYRAZINYL)AMINO)ETHYL)-4-PIPERIDINYL)-METHYL-4-AMINO-5 -CHLORO-2,3-DIHYDRO-7-BENZOFURANCARBOXYLATE | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-10-05 | — | — | US | disclosed |
| US-20030153573-A1 | Novel N-substituted 4-((-4'-aminobenzoyl)-oxymethyl)-piperidines having gastric prokinetic properties | BOSMANS JEAN-PAUL RENE MARIE (BE) | 2003-08-14 | — | — | US | disclosed |
| EP-0885190-B1 | N-SUBSTITUTED 4-((4'-AMINOBENZOYL)-OXYMETHYL)-PIPERIDINES HAVING GASTRIC PROKINETIC PROPERTIES | JANSSEN PHARMACEUTICA NV (BE) | 2003-05-07 | — | — | EP | disclosed |
| US-6509339-B2 | Gastrointestinal disorders; cardiovascular disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-01-21 | — | — | US | disclosed |
| US-20020042430-A1 | Novel esters of 1, 4-disubstituted piperidine derivatives | BOSMANS JEAN-PAUL RENE MARIE (BE) | 2002-04-11 | — | — | US | disclosed |
| US-6291481-B1 | CONDITIONS RELATED TO A HAMPERED OR IMPAIRED GASTRIC EMPTYING AND MORE GENERALLY TO TREAT CONDITIONS RELATED TO A HAMPERED OR IMPAIRED GASTROINTESTINAL TRANSIT. | JANSSEN PHARMACEUTICA, N.V. (BE) | 2001-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020042430-A1 | Novel esters of 1, 4-disubstituted piperidine derivatives | CBR1, ALK, ESRRA | HTR4 388/4885HTR3A 376/4885HTR2C 206/4885 |
| US-20030153573-A1 | Novel N-substituted 4-((-4'-aminobenzoyl)-oxymethyl)-piperidines having gastric prokinetic properties | GIPR, CRHR1, GRPR | HTR4 65/4885HTR3A 155/4885HTR2C 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.