Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 9/20 | 0.62 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PPID | Q08752 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9642301 | 0.87 | CYP11B1 (0.77) | CYP11B1CYP11B2IDO1FNTAFNTB | |
| SCHEMBL2789863 | 0.86 | CYP11B1 (0.76) | CYP11B1CYP11B2IDO1FNTAFNTB | |
| SCHEMBL9123088 | 0.85 | CYP11B1 (0.67) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL2789150 | 0.82 | CYP11B1 (0.61) | CYP11B1CYP11B2IDO1FNTAFNTB | |
| Hydrochloric Acid SCHEMBL8763109 | 0.80 | CYP11B1 (0.60) | CYP11B1CYP11B2IDO1FNTAFNTB | |
| SCHEMBL6781178 | 0.80 | CYP11B1 (0.47) | CYP11B1CYP11B2 | |
| SCHEMBL9267101 | 0.79 | CYP11B1 (0.58) | CYP11B1CYP11B2ALDH1A1IDO1FNTA | |
| SCHEMBL27306308 | 0.79 | CYP11B1 (0.52) | CYP11B1CYP11B2ALDH1A1IDO1TSHR | |
| SCHEMBL16380792 | 0.78 | CYP11B1 (0.57) | CYP11B1CYP11B2ALDH1A1MAPTIDO1 | |
| SCHEMBL7259729 | 0.78 | CYP11B1 (0.61) | CYP11B1CYP11B2ALDH1A1IDO1FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040171844-A1 | Dihydro-2H-naphthalene-1-one inhibitors of ras farnesyl transferase | LEONARD DANIELE MARIE (US) | 2004-09-02 | — | — | US | disclosed |
| US-20030232790-A1 | Dihydro-2h-napthalene-1-one inhibitors of ras farnesyl transferase | WARNER-LAMBERT COMPANY | 2003-12-18 | — | — | US | disclosed |
| EP-1276724-A2 | DIHYDRO-2H-NAPHTHALENE-1-ONE INHIBITORS OF RAS FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001079179-A2 | DIHYDRO-2H-NAPHTHALENE-1-ONE INHIBITORS OF RAS FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 2001-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171844-A1 | Dihydro-2H-naphthalene-1-one inhibitors of ras farnesyl transferase | NRAS, HRAS, FNTB | CYP11B1 507/4885CYP11B2 1099/4885ALDH1A1 1270/4885 |
| US-20030232790-A1 | Dihydro-2h-napthalene-1-one inhibitors of ras farnesyl transferase | NRAS, FNTA, CYP46A1 | CYP11B1 206/4885CYP11B2 430/4885ALDH1A1 491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.