Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 4/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylamine SCHEMBL6776180 | 0.83 | ATM (0.45) | ATMMAP4K4BRD4DRD2CSNK2A2 | |
| SCHEMBL6776474 | 0.82 | AXL (0.40) | ATMKDR | |
| SCHEMBL6780330 | 0.82 | KDR (0.39) | ATMKDR | |
| SCHEMBL6776188 | 0.78 | MAP4K4 (0.39) | ATMMAP4K4KDRENPP1 | |
| SCHEMBL7141642 | 0.72 | STK17B (0.39) | BRD4MEN1GAAKMT2A | |
| SCHEMBL7625181 | 0.72 | MAP4K4 (0.40) | ATMMAP4K4KDRENPP1 | |
| Methylamine SCHEMBL6780338 | 0.68 | HDAC3 (0.43) | ATMKDR | |
| Methylamine SCHEMBL6776480 | 0.67 | AXL (0.41) | ATMKDR | |
| SCHEMBL5911734 | 0.65 | ENPP1 (0.52) | ATMBRD4KDRENPP1 | |
| SCHEMBL4431432 | 0.65 | ADRA2A (0.47) | ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806274-B1 | IMMUNOREGULATION OR IMMUNOSUPPRESSIVE AGENTS; TYROSINE KINASE INHIBITORS; PREVENTING ORGAN TRANSPLANT REJECTION; AUTOIMMUNE CONDITIONS; REDUCED SIDE EFFECTS | ASTRAZENECA UK LIMITED (GB) | 2004-10-19 | — | — | US | disclosed |