Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 3/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 4/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7625181 | 0.85 | MAP4K4 (0.40) | ATMMAP4K4HDAC3HDAC4HDAC1 | |
| SCHEMBL6776188 | 0.83 | MAP4K4 (0.39) | ATMMAP4K4HDAC3HDAC4HDAC1 | |
| SCHEMBL6776169 | 0.83 | ATM (0.42) | ATMMAP4K4CSNK2A2CSNK2A1BRD4 | |
| Methylamine SCHEMBL6776480 | 0.82 | AXL (0.41) | ATMHDAC3HDAC4HDAC1HDAC7 | |
| Methylamine SCHEMBL6780338 | 0.81 | HDAC3 (0.43) | ATMHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6776176 | 0.74 | SRC (0.37) | MAP4K4HDAC3HDAC4HDAC1HDAC7 | |
| Methylamine SCHEMBL7141650 | 0.72 | ADORA3 (0.42) | CSNK2A2CSNK2A1BRD4ADORA3CA12 | |
| SCHEMBL4430373 | 0.70 | ALDH1A1 (0.36) | MAP4K4HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4420153 | 0.70 | KDM4E (0.52) | ATMMAP4K4ADORA3EGFRLYN | |
| SCHEMBL4420146 | 0.70 | PDE5A (0.41) | MAP4K4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806274-B1 | IMMUNOREGULATION OR IMMUNOSUPPRESSIVE AGENTS; TYROSINE KINASE INHIBITORS; PREVENTING ORGAN TRANSPLANT REJECTION; AUTOIMMUNE CONDITIONS; REDUCED SIDE EFFECTS | ASTRAZENECA UK LIMITED (GB) | 2004-10-19 | — | — | US | disclosed |