Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6777054 | 0.90 | EDNRA (0.46) | EDNRA | |
| SCHEMBL6776271 | 0.84 | EDNRA (0.46) | EDNRA | |
| SCHEMBL6776269 | 0.80 | EDNRA (0.45) | EDNRA | |
| SCHEMBL6777477 | 0.79 | EDNRA (0.42) | EDNRA | |
| SCHEMBL6771344 | 0.79 | EDNRB (0.43) | EDNRA | |
| SCHEMBL6772980 | 0.79 | EDNRB (0.41) | EDNRA | |
| SCHEMBL6772649 | 0.78 | TDP1 (0.34) | — | |
| SCHEMBL8056643 | 0.78 | EDNRA (0.43) | EDNRA | |
| SCHEMBL6767823 | 0.76 | EDNRB (0.42) | EDNRA | |
| SCHEMBL6777059 | 0.74 | EDNRA (0.46) | EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673824-B1 | HYPOTENSIVE AGENTS | BRISTOL-MYERS SQUIBB CO. | 2004-01-06 | — | — | US | disclosed |
| US-6107320-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | disclosed |
| US-5514696-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1996-05-07 | — | — | US | disclosed |