Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 3/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.37 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 2/20 | 0.36 |
| ▸ | MAX | P61244 | 2/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | RARG | P13631 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6361867 | 0.83 | KMT2A (0.49) | TP53ALDH1A1TSHRKMT2A | |
| SCHEMBL11551863 | 0.82 | PTGER1 (0.43) | TP53XDHDHODHSCN5ASCN9A | |
| SCHEMBL2405699 | 0.80 | TP53 (0.41) | TP53DHODHALDH1A1TSHRKMT2A | |
| SCHEMBL25704057 | 0.79 | POLB (0.42) | DHODHALDH1A1KMT2A | |
| SCHEMBL6624693 | 0.79 | KDM4E (0.45) | TP53RARARARBRARGALDH1A1 | |
| SCHEMBL23525777 | 0.78 | ALDH1A1 (0.46) | ALDH1A1TSHR | |
| SCHEMBL5446405 | 0.72 | ALDH1A1 (0.49) | DHODHNR1H4MYCALDH1A1TSHR | |
| SCHEMBL7584370 | 0.72 | XDH (0.41) | TP53XDHDHODHNR1H4MAP3K7 | |
| SCHEMBL1853295 | 0.71 | KDM4C (0.52) | TP53XDHDHODHSLC22A12NR1H4 | |
| SCHEMBL7432976 | 0.71 | ALDH1A1 (0.47) | DHODHNR1H4MYCALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756373-B1 | SUCH AS 5-(2-BUTOXY-5-IODO-3-PYRIDINYL)-3-ETHYL-2-(2-METHOXY-ETHYL)-2,6-DIHYDRO-7H -PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE; CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS; ERECTILE DYSFUNCTION | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |