Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 12/20 | 0.44 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.37 |
| ▸ | BAD | Q92934 | 3/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6896741 | 0.90 | PLA2G2A (0.41) | PLA2G2APLA2G10PLA2G1BPLA2G5MCL1 | |
| SCHEMBL6775731 | 0.88 | PLA2G2A (0.46) | PLA2G2APLA2G10PLA2G1BPLA2G5BCAT2 | |
| SCHEMBL6774300 | 0.87 | PLA2G2A (0.48) | PLA2G2APLA2G10PLA2G1BPLA2G5BCAT2 | |
| SCHEMBL6774281 | 0.87 | PLA2G2A (0.40) | PLA2G2AKCNH2 | |
| SCHEMBL6774469 | 0.86 | PLA2G2A (0.41) | PLA2G2APLA2G10PLA2G1BPLA2G5 | |
| SCHEMBL6776187 | 0.86 | ALDH1A1 (0.42) | — | |
| SCHEMBL6770455 | 0.86 | CD38 (0.38) | PLA2G2APPARG | |
| SCHEMBL6775004 | 0.86 | ALDH1A1 (0.42) | PLA2G2A | |
| SCHEMBL6689186 | 0.86 | PLA2G2A (0.46) | PLA2G2APLA2G10PLA2G1BPLA2G5PPARG | |
| SCHEMBL6768790 | 0.86 | PLA2G2A (0.48) | PLA2G2APLA2G10PLA2G1BPLA2G5BCAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |