Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 9/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6689186 | 0.90 | PLA2G2A (0.46) | PLA2G2APLA2G1BADRB2ADRB1ADRA1D | |
| SCHEMBL6896161 | 0.90 | HSP90AA1 (0.40) | PLA2G2APLA2G1BCYP2D6ALDH1A1CYP1A2 | |
| SCHEMBL6774350 | 0.89 | PLA2G2A (0.40) | PLA2G2APLA2G1BIDH1PLA2G10PLA2G5 | |
| SCHEMBL6774281 | 0.89 | PLA2G2A (0.40) | PLA2G2AKDM4EALDH1A1LMNAHSD17B10 | |
| SCHEMBL6775713 | 0.87 | PLA2G2A (0.43) | PLA2G2APLA2G1BADRA1DCYP2D6CYP1A2 | |
| SCHEMBL6777538 | 0.86 | PLA2G2A (0.44) | PLA2G2APLA2G1BPLA2G10PLA2G5 | |
| SCHEMBL6776234 | 0.86 | PLA2G2A (0.47) | PLA2G2APLA2G1BADRA1DPLA2G10PLA2G5 | |
| SCHEMBL6770455 | 0.86 | CD38 (0.38) | PLA2G2AALDH1A1 | |
| SCHEMBL6775004 | 0.86 | ALDH1A1 (0.42) | PLA2G2AADRA1DCYP2D6KDM4EALDH1A1 | |
| SCHEMBL6776187 | 0.86 | ALDH1A1 (0.42) | CYP2D6KDM4EALDH1A1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |