Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 2/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 11/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6772142 | 0.89 | MAPT (0.59) | ADRB1ADRB2ADRB3MAPTMAPK1 | |
| SCHEMBL6778522 | 0.86 | MAPT (0.65) | ADRB1MAPTMAPK1KDM4ENPSR1 | |
| Hydrochloric Acid SCHEMBL7885529 | 0.83 | MAPT (0.67) | ADRB1ADRB2ADRB3MAPTMAPK1 | |
| SCHEMBL8433535 | 0.82 | SCN9A (0.56) | ADRB1ADRB2ADRB3MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL7887645 | 0.82 | MAPT (0.73) | ADRB1MAPTMAPK1KDM4EHTR1A | |
| Hydrochloric Acid SCHEMBL7885717 | 0.82 | MAPT (0.73) | ADRB1MAPTMAPK1KDM4EHTR1A | |
| SCHEMBL6776715 | 0.81 | CACNA1G (0.57) | MAPTLMNAMEN1KMT2AKCNH2 | |
| SCHEMBL7881247 | 0.80 | MAPT (0.54) | ADRB1ADRB2ADRB3MAPTMAPK1 | |
| SCHEMBL7883003 | 0.80 | ABCB1 (0.65) | ADRB1MAPTMAPK1KDM4EHTR1A | |
| SCHEMBL7883018 | 0.79 | HTR1A (0.55) | ADRB1ADRB2ADRB3MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020035112-A1 | Antipsychotic indolyl derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-03-21 | — | — | US | claimed |
| US-6310066-B1 | 1-(4-CHLORO-PHENOXY)-3-(4-(1H-INDOL-4-YL)-PIPERAZIN-1-YL)-PROPAN-2-OL FOR EXAMPLE | AMERICAN HOME PRODUCTS CORP. | 2001-10-30 | — | — | US | claimed |
| EP-1076647-A2 | ANTIPSYCHOTIC INDOLYL DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-21 | — | — | EP | claimed |
| WO-1999055672-A2 | ANTIPSYCHOTIC INDOLYL DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-04 | — | — | WO | claimed |
| US-6689792-B2 | USEFUL FOR THE TREATMENT OF SCHIZOPHRENIA AND RELATED PSYCHOTIC DISORDERS SUCH AS PARKINSON'S DISEASE AND ALZHEIMER'S DISEASE | WYETH | 2004-02-10 | — | — | US | disclosed |
| US-20020035112-A1 | Antipsychotic indolyl derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-03-21 | — | — | US | disclosed |
| US-6310066-B1 | 1-(4-CHLORO-PHENOXY)-3-(4-(1H-INDOL-4-YL)-PIPERAZIN-1-YL)-PROPAN-2-OL FOR EXAMPLE | AMERICAN HOME PRODUCTS CORP. | 2001-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020035112-A1 | Antipsychotic indolyl derivatives | DRD4, HTR4, DBH | ADRB1 106/4885ADRB2 98/4885ADRB3 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.