Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 2/20 | 0.53 |
| ▸ | EDNRB | P24530 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6772781 | 0.84 | EDNRA (0.53) | EDNRAEDNRBOPRM1OPRK1KCNH2 | |
| SCHEMBL6776216 | 0.84 | EDNRA (0.53) | EDNRAEDNRBOPRM1OPRK1KCNH2 | |
| SCHEMBL9572126 | 0.83 | EDNRA (0.52) | EDNRAEDNRBOPRM1OPRK1KCNH2 | |
| SCHEMBL6771771 | 0.80 | EDNRA (0.52) | EDNRAEDNRBOPRM1OPRK1KCNH2 | |
| SCHEMBL6771873 | 0.80 | EDNRA (0.58) | EDNRAEDNRBOPRM1OPRK1KCNH2 | |
| SCHEMBL1458690 | 0.79 | CES2 (0.41) | OPRM1OPRK1KCNH2 | |
| SCHEMBL3893623 | 0.76 | POLB (0.46) | EDNRAEDNRB | |
| SCHEMBL8597480 | 0.76 | PTGS2 (0.47) | EDNRAEDNRB | |
| SCHEMBL15849847 | 0.76 | PTGS2 (0.47) | EDNRAEDNRB | |
| SCHEMBL232659 | 0.75 | CASP1 (0.47) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673824-B1 | HYPOTENSIVE AGENTS | BRISTOL-MYERS SQUIBB CO. | 2004-01-06 | — | — | US | disclosed |
| US-6107320-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | disclosed |
| US-5514696-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1996-05-07 | — | — | US | disclosed |