Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 2/20 | 0.38 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6361822 | 0.81 | PLA2G10 (0.41) | PLA2G10PLA2G5TSHRSCN9ASCN10A | |
| SCHEMBL1364804 | 0.75 | TSHR (0.54) | PLA2G10PLA2G5TSHRKDM4EALDH1A1 | |
| SCHEMBL6334079 | 0.74 | TSHR (0.49) | PLA2G10PLA2G5TSHRKDM4EALDH1A1 | |
| SCHEMBL11042645 | 0.73 | TSHR (0.47) | PLA2G10PLA2G5TSHRKDM4EALDH1A1 | |
| SCHEMBL7555011 | 0.72 | TSHR (0.38) | PLA2G10PLA2G5TSHRKDM4EALDH1A1 | |
| SCHEMBL30170292 | 0.72 | LMNA (0.47) | TSHRALDH1A1 | |
| SCHEMBL6282329 | 0.68 | PLA2G10 (0.47) | PLA2G10PLA2G5SCN9ASCN10AKDM4E | |
| SCHEMBL20481291 | 0.67 | POLB (0.42) | PLA2G10PLA2G5 | |
| SCHEMBL9823072 | 0.66 | TSHR (0.44) | TSHRKDM4EALDH1A1 | |
| SCHEMBL6283587 | 0.66 | LMNA (0.48) | PLA2G10PLA2G5SCN9ASCN10AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1208089-B1 | DIAZOCIN-DIONE DERIVATIVES AND THEIR USE AS TRYPTASE INHIBITORS | ALTANA PHARMA AG (DE) | 2004-10-13 | — | — | EP | disclosed |
| US-6673786-B1 | TREATING ALLERGIC OR INFLAMMATORY DISORDERS | ALTANA PHARMA AG (DE) | 2004-01-06 | — | — | US | disclosed |
| EP-1208089-A2 | DIAZOCIN-DIONE DERIVATIVES AND THEIR USE AS TRYPTASE INHIBITORS | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2002-05-29 | — | — | EP | disclosed |
| WO-2001010848-A2 | DIAZOCIN-DIONE DERIVATIVES AND THEIR USE S TRYPTASE INHIBITORS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2001-02-15 | — | — | WO | disclosed |