Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | LPAR1 | Q92633 | 6/20 | 0.52 |
| ▸ | LPAR5 | Q9H1C0 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6784816 | 0.86 | PTGES (0.60) | NPC1RAB9ALPAR1LPAR5ALDH1A1 | |
| SCHEMBL6779305 | 0.86 | PTGES (0.53) | NPC1RAB9ALPAR1LPAR5MEN1 | |
| SCHEMBL6783932 | 0.83 | NPC1 (0.70) | NPC1RAB9AMEN1KMT2AACHE | |
| SCHEMBL6778659 | 0.83 | ALDH1A1 (0.49) | MEN1KMT2ATDP1ALDH1A1BCL2A1 | |
| SCHEMBL30958894 | 0.82 | POLB (0.62) | NPC1RAB9ALPAR1MEN1KMT2A | |
| SCHEMBL22100763 | 0.82 | NPC1 (0.65) | NPC1RAB9ALPAR1LPAR5MEN1 | |
| SCHEMBL30522587 | 0.81 | NPC1 (0.70) | NPC1RAB9AMEN1KMT2AACHE | |
| SCHEMBL14542054 | 0.78 | TSPO (0.62) | TSHRALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL6775052 | 0.77 | HTT (0.49) | LPAR1MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL5491922 | 0.76 | NPC1 (0.68) | NPC1RAB9AMEN1KMT2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020156281-A1 | Amide inhibitors of microsomal triglyceride transfer protein | BOOTH RICHARD JOHN (US) | 2002-10-24 | — | — | US | claimed |
| US-6780883-B2 | ANTICHOLESTEROL AGENTS; CARDIOVASCULAR DISORDERS; ANTILIPEMIC AGENTS; RESTENOSIS; DIETETICS | WARNER-LAMBERT COMPANY | 2004-08-24 | — | — | US | disclosed |
| US-20020156281-A1 | Amide inhibitors of microsomal triglyceride transfer protein | BOOTH RICHARD JOHN (US) | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156281-A1 | Amide inhibitors of microsomal triglyceride transfer protein | CETP, MTTP, LCAT | NPC1 35/4885RAB9A 2995/4885LPAR1 2233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.