Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.74 |
| ▸ | HPGD | P15428 | 5/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | TOP2A | P11388 | 1/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.74 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | BRD4 | O60885 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | CASP9 | P55211 | 1/20 | 0.53 |
| ▸ | BAX | Q07812 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1706011 | 0.91 | KDM4E (0.69) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL14616028 | 0.90 | KDM4E (0.68) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL29576777 | 0.90 | ALDH1A1 (0.66) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL9638922 | 0.90 | ALDH1A1 (0.66) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL8983611 | 0.89 | KDM4E (0.78) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL9500971 | 0.89 | KDM4E (0.81) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL29475791 | 0.89 | KDM4E (0.79) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL8038539 | 0.89 | KDM4E (0.79) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL9158179 | 0.88 | KDM4E (0.68) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL9152004 | 0.88 | KDM4E (0.68) | KDM4EALDH1A1HPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11059788-B2 | Streamlined syntheses of fluoroquinolones | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2021-07-13 | — | — | US | disclosed |
| US-11059788-B2 | Streamlined syntheses of fluoroquinolones | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2021-07-13 | — | — | US | disclosed |
| US-20200123111-A1 | STREAMLINED SYNTHESES OF FLUOROQUINOLONES | VIRGINIA COMMONWEALTH UNIVERSITY | 2020-04-23 | — | — | US | disclosed |
| US-20200123111-A1 | STREAMLINED SYNTHESES OF FLUOROQUINOLONES | VIRGINIA COMMONWEALTH UNIVERSITY | 2020-04-23 | — | — | US | disclosed |
| EP-3638648-A2 | STREAMLINED SYNTHESES OF FLUOROQUINOLONES | Virginia Commonwealth University (US) | 2020-04-22 | — | — | EP | disclosed |
| CN-111032622-A | Streamlined synthetic fluoroquinolones | 弗吉尼亚联邦大学 | 2020-04-17 | — | — | CN | disclosed |
| WO-2018231747-A2 | STREAMLINED SYNTHESES OF FLUOROQUINOLONES | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2018-12-20 | — | — | WO | disclosed |
| US-10087165-B2 | Fluoroquinolones and use thereof to treat bacterial infections | SORBONNE UNIVERSITE (FR) | 2018-10-02 | — | — | US | disclosed |
| US-20170144992-A1 | NOVEL FLUOROQUINOLONES AND USE THEREOF TO TREAT BACTERIAL INFECTIONS | UNIVERSITÉ PIERRE ET MARIE CURIE - PARIS 6 (UPMC) (FR) | 2017-05-25 | — | — | US | disclosed |
| US-20170144992-A1 | NOVEL FLUOROQUINOLONES AND USE THEREOF TO TREAT BACTERIAL INFECTIONS | UNIVERSITÉ PIERRE ET MARIE CURIE - PARIS 6 (UPMC) (FR) | 2017-05-25 | — | — | US | disclosed |
| EP-2957561-A1 | Novel fluoroquinolones and use thereof to treat bacterial infections | Université Paris 6 Pierre et Marie Curie UPMC (FR) | 2015-12-23 | — | — | EP | disclosed |
| EP-1401829-B1 | NOVEL HETEROCYCLIC ANTIBACTERIAL COMPOUNDS | MICROBIOTIX INC (US) | 2012-08-22 | — | — | EP | disclosed |
| US-6777420-B2 | A URACIL COMPOUNDS AS ENZYME INHIBITORS, INHIBIT BACTERIAL DNA POLYMERASE, TREATING BACTERIAL DISEASES | MICROBIOTIX, INC. | 2004-08-17 | — | — | US | disclosed |
| US-20030181719-A1 | Novel heterocyclic antibacterial compounds | MICROBIOTIX, INC. | 2003-09-25 | — | — | US | disclosed |
| WO-2001002365-A1 | CIPROFLOXACIN HYDRATES AND METHOD FOR THEIR PRODUCTION | BAYER AKTIENGESELLSCHAFT (DE) | 2001-01-11 | — | — | WO | disclosed |
| US-5914401-A | Methods for the manufacture of quinolone carboxylic acids derivatives and intermediates thereof | APOTEX, INC. (CA) | 1999-06-22 | — | — | US | disclosed |
| US-5281596-A | Treatment with 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-ethylpiperazino)quinoline-3 -carboxylic acid or salt | BAYER AKTIENGESELLSCHAFT (DE) | 1994-01-25 | — | — | US | disclosed |
| EP-0238814-B1 | ANTIBACTERIAL MEDICAMENTS FOR FISH | BAYER AG (DE) | 1992-06-24 | — | — | EP | disclosed |
| EP-0238814-A2 | Antibacterial medicaments for fish | BAYER AG (DE) | 1987-09-30 | — | — | EP | disclosed |
| CN-87100799-A | ANTIBACTERIAL DRUGS FOR FISH | — | 1987-09-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181719-A1 | Novel heterocyclic antibacterial compounds | TOP1, TOP2A, TOP2B | KDM4E 2689/4885ALDH1A1 2897/4885HPGD 707/4885 |
| US-10087165-B2 | Fluoroquinolones and use thereof to treat bacterial infections | CFTR, NQO2, FPR1 | KDM4E 3086/4885ALDH1A1 4095/4885HPGD 755/4885 |
| US-20170144992-A1 | NOVEL FLUOROQUINOLONES AND USE THEREOF TO TREAT BACTERIAL INFECTIONS | CFTR, IRF3, FPR1 | KDM4E 3242/4885ALDH1A1 4490/4885HPGD 1216/4885 |
| US-20200123111-A1 | STREAMLINED SYNTHESES OF FLUOROQUINOLONES | NRAS, QARS1, BLM | KDM4E 1424/4885ALDH1A1 3504/4885HPGD 1095/4885 |
| US-11059788-B2 | Streamlined syntheses of fluoroquinolones | NRAS, QARS1, BLM | KDM4E 1424/4885ALDH1A1 3504/4885HPGD 1095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.