Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 4/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28225801 | 0.79 | CYP2D6 (0.41) | GRIN1GRIN2AGRIN2DGRIN2CGRIN2B | |
| SCHEMBL416118 | 0.78 | GRIN1 (0.47) | GRIN1GRIN2AGRIN2DGRIN2CGRIN2B | |
| SCHEMBL18251092 | 0.75 | ALDH1A1 (0.43) | GRIN1GRIN2AGRIN2DGRIN2CGRIN2B | |
| SCHEMBL6781624 | 0.75 | TSHR (0.43) | GRIN1GRIN2AGRIN2DGRIN2CGRIN2B | |
| SCHEMBL4454908 | 0.74 | GRIN1 (0.43) | GRIN1GRIN2AGRIN2DGRIN2CGRIN2B | |
| SCHEMBL6284917 | 0.71 | GRIN1 (0.44) | GRIN1GRIN2AGRIN2DGRIN2CGRIN2B | |
| SCHEMBL16428269 | 0.71 | TSHR (0.43) | GRIN1GRIN2AGRIN2DGRIN2CGRIN2B | |
| SCHEMBL1067596 | 0.70 | TSHR (0.39) | TSHRCYP2D6CYP3A4ALDH1A1MAPT | |
| SCHEMBL678931 | 0.69 | KMT2A (0.48) | LMNATSHRCYP2D6CYP3A4CYP2C19 | |
| SCHEMBL14164384 | 0.68 | GRIN1 (0.50) | GRIN1GRIN2AGRIN2DGRIN2CGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686369-B1 | α-hydrdroxylic acid derivatives, their production and use | ABBOTT GMBH & CO., KG (DE) | 2004-02-03 | — | — | US | disclosed |
| EP-0892787-B1 | NOVEL ALPHA-HYDROXYLIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | ABBOTT GMBH & CO KG (DE) | 2003-06-11 | — | — | EP | disclosed |
| EP-0892787-A1 | NOVEL $g(a)-HYDROXYLIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038981-A1 | NOVEL α-HYDROXYLIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1997-10-23 | — | — | WO | disclosed |