Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.65 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.65 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.65 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.65 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.65 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.65 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.65 |
| ▸ | CCKBR | P32239 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6782014 | 0.82 | GABRA1 (0.76) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Ro-052921 SCHEMBL29979594 | 0.81 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Ro-052921 SCHEMBL1365706 | 0.81 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11002761 | 0.79 | CCKBR (0.45) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL6784853 | 0.79 | CCKBR (0.45) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11543658 | 0.71 | GABRA1 (0.78) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL2615411 | 0.71 | GABRA1 (0.78) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL2615408 | 0.71 | GABRA1 (0.78) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL5356267 | 0.70 | GABRA1 (0.72) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL8726318 | 0.70 | GABRA1 (0.72) | GABRA1GABRA5GABRA3GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6683075-B1 | FUSED NITROGENHETEROCYCLIC AMIDES; ALZHEIMER'S DISEASE | ATHENA NEUROSCIENCES, INC. | 2004-01-27 | — | — | US | disclosed |