Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.36 |
| ▸ | MMP9 | P14780 | 7/20 | 0.36 |
| ▸ | MMP3 | P08254 | 4/20 | 0.36 |
| ▸ | MMP13 | P45452 | 3/20 | 0.36 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.33 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6787718 | 0.81 | LMNA (0.44) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL6795116 | 0.79 | MMP2 (0.38) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL6790501 | 0.77 | ALDH1A1 (0.47) | MMP2HPGDSMN1; SMN2ADAMTS5ALDH1A1 | |
| SCHEMBL7448510 | 0.76 | ALDH1A1 (0.46) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL6784793 | 0.76 | ALDH1A1 (0.46) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL6796186 | 0.74 | MMP2 (0.62) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL6783185 | 0.74 | MMP2 (0.62) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL6783118 | 0.74 | MMP2 (0.62) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL6788702 | 0.73 | MMP2 (0.45) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL6789943 | 0.73 | ALDH1A1 (0.43) | MMP2MMP9MMP3MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200398-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2002-05-02 | — | — | EP | claimed |
| WO-2001005756-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-01-25 | — | — | WO | claimed |
| US-6765003-B1 | ANTICARCINOGENIC, ANTITUMOR, AND ANTIMETASTASIS AGENTS; RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, MULTIPLE SCLEROSIS, STROKE, ARTERIOSCLEROSIS, | PHARMACIA ITALIA, SPA (IT) | 2004-07-20 | — | — | US | disclosed |
| EP-1200398-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001005756-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-01-25 | — | — | WO | disclosed |